[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 25, Issue 1 (5-2017) ::
Journal of Ilam University of Medical Sciences 2017, 25(1): 33-44 Back to browse issues page
Investigating the Effects of Ferula Szowitsiana (Ferula szowitsiana L.) on Antioxidant System Parameters in the Hippocampus of Male Rats to Follow Inducemultiple Sclerosis Disease
Somayeh Abdi1, Homira Hatami Nemati *2, Roghayeh Khakpay1, Gholam reza Dehghan1
1- University of Tabriz
2- University of Tabriz , homeirahatami@yahoo.com
Abstract:   (5079 Views)

Introduction: Oxidative stress is resulting from the imbalance between free radicals and antioxidant system of the body. Increased oxidative stress in the brain causes impaired brain activity, neuronal death, and diseases such as multiple sclerosis (MS). In this study, the protective effect of Ferula szowitsiana plant against oxidative stress caused by cerebral ventricular injection of ethidium bromide was evaluated.

Materials & methods: With direct single injection of 0.01 % ethidium bromide (EB) into the Cornu ammonis (CA1) of hippocampal formation the induction of MS was done. One week after MS induction, animals received intrahippocampal (5 μg/rat and 10 μg/rat) administration of the extract for 3 consecutive days. At the end, the bilateral hippocampi was dissected and used for the measurement of oxidative stress markers. Statistical analysis of the obtained data was performed using one-way ANOVA.

Findings: Hippocampal injection of EB caused significant increment of total antioxidant capacity (p< 0.001) and activity of antioxidant enzymes SOD and decrease activity of CAT (p< 0.01). Short-term local injection of Ferula szowitsiana extract significantly reduced the total antioxidant capacity (p< 0.001) and activity of CAT and SOD enzymes (p< 0.001) to the normal levels.

Discussion & conclusions: The results of the present study show that local injection of EB cause increasing production of the free radicals. The Ferula szowitsiana extract as a potent antioxidant modulates oxidative stress markers, probably through scavenging of reactive oxygen species )ROS( and clearing of free radicals from the cellular milieu.

Keywords: Oxidative stress, Multiple sclerosis, Ferula szowitsiana
Full-Text [PDF 791 kb]   (1757 Downloads)    
Type of Study: Research |
Received: 2015/11/16 | Accepted: 2016/01/18 | Published: 2017/05/2
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Abdi S, Hatami Nemati H, Khakpay R, Dehghan G R. Investigating the Effects of Ferula Szowitsiana (Ferula szowitsiana L.) on Antioxidant System Parameters in the Hippocampus of Male Rats to Follow Inducemultiple Sclerosis Disease. Journal of Ilam University of Medical Sciences 2017; 25 (1) :33-44
URL: http://sjimu.medilam.ac.ir/article-1-3188-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 25, Issue 1 (5-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.14 seconds with 30 queries by YEKTAWEB 4541