[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
Publication Ethics::
Peer Review Process::
Indexing Databases::
For Authors::
For Reviewers::
Subscription::
Contact us::
Site Facilities::
::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Citations63163624
h-index2719
i10-index18678

..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Registered in

AWT IMAGE

AWT IMAGE

..
:: Volume 25, Issue 1 (5-2017) ::
Journal of Ilam University of Medical Sciences 2017, 25(1): 1-11 Back to browse issues page
The Effect of a Continuous Training on Necrosis and Apoptosis Changes in the Hippocampus of Diabetic Rats
Nabi Shamsaei * 1, Hadi Abdi2 , Morteza Shamsi3
1- Dept of Physical Education and Sports Science, Faculty of Literature and Humanities, Ilam University, Ilam, Iran , shamsaeinabi@gmail.com
2- Dept of Physical Education, Payame Noor University, Tehran, Iran
3- Dept of Parasitology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
Abstract:   (7496 Views)

Introduction: Diabetes is associated with different neurological disorders in the nervous system that will eventually lead to cell damage. The previous studies have shown the beneficial effects of exercise on brain damage caused by diabetic neuropathy in animal models. In the present study, the effect of aerobic exercise training on cell death in the hippocampal CA1 area neurons in diabetic male rats was investigated.

Materials & methods: 21 adult male Wistar rats (weighing 260-300 g) were purchased from Tehran Pasteur Institute and were randomly divided into three groups: sham group, diabetic group and diabetic + exercise training group (7 rats per group). Diabetes was induced intraperitoneally streptozotocin (STZ) administration at the dose of 60mg/kg. The diabetes criterion was the blood glucose level higher than 250 mg/dl. One week after induction of diabetes, the rats in exercise training group were trained to run on a treadmill 5 days a week for 4 weeks. Necrotic cell death was detected by Nissl staining and apoptosis was detected by TUNEL staining.

Findings: The results showed that aerobic exercise training significantly reduced the diabetes-induced necrotic cell death (p<0.01) and apoptosis (p<0.05) in the hippocampal CA1 area neurons.

Discussion & conclusions: This study showed that aerobic exercise training has neuroprotective effects against diabetic neuropathy. This neuroprotective mechanism of exercise can be an effective way to reduce cerebral complications of diabetes. 

Keywords: Exercise training, Diabetes, Necrosis, Apoptosis
Full-Text [PDF 849 kb]   (3986 Downloads)    
Type of Study: Research |
Received: 2015/10/20 | Accepted: 2015/12/26 | Published: 2017/04/22
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Shamsaei N, Abdi H, Shamsi M. The Effect of a Continuous Training on Necrosis and Apoptosis Changes in the Hippocampus of Diabetic Rats. J. Ilam Uni. Med. Sci. 2017; 25 (1) :1-11
URL: http://sjimu.medilam.ac.ir/article-1-3141-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 25, Issue 1 (5-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.17 seconds with 40 queries by YEKTAWEB 4646