Introduction: Diabetes is a metabolic and chronic disorder. One of the safe treatments in diabetes disease is the use of herbal plants in traditional medicine. The aim of this study was to consider the antioxidant and anti-inflammation effectof ziziphus vulgaris (jujube) in contrast with diabetes.

Materials & methods: In this study, 30 Wistar rats were studied in three groups including control diabetic, non control diabetic and treatment group for 5 weeks. The animals intreatment group were treated with the powder of jujube (1 g/kg bw) for two weeks. After two weeks, stereptozotocin (60 mg/kg bw) was used for induced diabetes in animal except non diabetic control group. Afterwards, the animals were treated for three weeks in the same way. At the end of the study the animal blood samples were taken and the antioxidant content of serum, malondialdehyde (MDA) and C-reactive protein (CRP) were measured. Data analysis was done by statistical tests as: Kruskalwallis and Wilcoxon singed ranks.

Findings:  The content of  MDA and CRP had a significant decrease in comparison with diabetic control group in animals that received the powder of jujube before induction of the diabetes (P>0/05). In the end of study, the content of serum antioxidant in the rats that treated with jujube showed a significant increase in comparison with diabetic rats too (P>0/05).

Discussion & conclusions: The jujube fruit has antioxidant and anti-inflammatory action and it is useful in preventing inflammation due to diabetes and diabetes treatment.