Introduction: Cerebral ischemic edema is one of the most important complication of cerebral stroke that result in intensification of early (primitive) ischemic lesion in brain. In this study, we determinate relationship between effect of pre-nutrition of flax seed oil on level of blood oils and the amount of cerebral edema in model of rat stroke.

Materials & methods: This study was performed on 5 groups included 7 male rats. Blank group received distil water, where 3treatment groups received flax seed oil by gavage 30 days. (0.25,0.50,0.75). For sham  group isn't performed treatment and  ischemic induction. Two hours after the last gavege, group operated by surgery of model MCAO(Middle Cerebral Artery Occlusion) for ischemic induction and study of cerebral ischemic and blood oils. Data were analyzed by test ANOVA investigation.

Findings: Pretreatment with flax seed oil resulted in decrease of cholesterol, triglycerides and LDL and also resulted in increase of level of HDL in doses of 0.50 and 0.75(P<0.05) Pretreatment by flax seed oil resulted in decrease of the amount of cerebral edema after MCAO in rat (P<0.05).

Discussion & Conclusion: Results of this study indicated that flax seed oil with doses of 0.50 and 0.75 protected ischemic rat in contrast to cerebral edema and decreased the amount of serum lipids.