[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 24, Issue 6 (2-2017) ::
Journal of Ilam University of Medical Sciences 2017, 24(6): 41-53 Back to browse issues page
Effects of Curcumin on Histologic Lesions of Testis Induced by Aflatoxin B1 in Rat Offspring before and after Puberty
Mohammad Nikoseyr Jahromi *1, Reza Ranjbar2, Mahmood Khaksar Mahabadi2, Hasan Morovati3, Hoseyn Najafzadehvarzi2
1- Dept of Basic Sciences, Faculty of Veterinary, Shahid Chamran University, Ahvaz, Iran , m_nikoosiar@yahoo.com
2- Dept of Basic Sciences, Faculty of Veterinary, Shahid Chamran University, Ahvaz, Iran
3- Dept of Basic Sciences, Faculty of Veterinary, Tehran University, Tehran, Iran
Abstract:   (5272 Views)

Introduction: This study was done to evaluate the use of curcumin to protect testicular tissue in offspring which their mother was exposed to aflatoxin.

Material & methods: Seventy adult female vistar rats were divided to control, sham and five experimental groups. Rats received serum physiology (the same volume a drugs), dimethyl sulfuxide (the same volume of drugs), Aflatoxin B1 (0.25 mg/kg), Aflatoxin B1 and curcumin (0.25 and 50 mg/kg), Aflatoxin B1 and curcumin (0.25 and 100 mg/kg), curcumin 50 mg/kg and curcumin 100 mg/kg intraperitoneally in the control and experimental groups. For histologic studies, testis samples were taken from male offspring at 1, 4 and 8 weeks. Samples fixed in formalin, 6µ thickness slides were prepared and stained with H&E.

Findings: In all times of sampling diameter of seminiferous tubule, number of germ cells and thickness of epithelium of seminiferous tubule in rats received aflatoxin decreased compared to control but these changes were not significant. In rats which received curcumin all parameters increased significantly.

Discussion & conclusion: Our results showed that curcumin could compensate undesirable effects of aflatoxin B1.

Keywords: Aflatoxin B1, Curcumin, Testis, Histology, Morphometry
Full-Text [PDF 1476 kb]   (2220 Downloads)    
Type of Study: Applicable | Subject: anatomy
Received: 2015/05/26 | Accepted: 2015/12/28 | Published: 2017/02/11
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Nikoseyr Jahromi M, Ranjbar R, Khaksar Mahabadi M, Morovati H, Najafzadehvarzi H. Effects of Curcumin on Histologic Lesions of Testis Induced by Aflatoxin B1 in Rat Offspring before and after Puberty. Journal of Ilam University of Medical Sciences 2017; 24 (6) :41-53
URL: http://sjimu.medilam.ac.ir/article-1-2738-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 24, Issue 6 (2-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.14 seconds with 31 queries by YEKTAWEB 4541