Introduction: Cardiovascular disease prevention in pediatrics is important. The aim of this research was to investigate the relationships and response of incremental exercise on inflammatory, immune and hormonal markers in pediatrics.

Materials & methods: Thirty healthy non-active pediatrics boys with the age range of 9-11 years old participated voluntarily in this study, and were randomly divided into control (C; n=11) and exercise group (E; n =11). Blood and salivary samples were collected in the two stages: prior to GXT (Graded exercise test) exercise test and immediately after graded exercise test. ELISA method was used for measurement of salivary immunoglobulin A, C-reaction protein, cortisol and fibrinogen serum levels. The research data were analyzed using the Pearson correlation coefficient, Multiple Linear Regression, independent and paired t test.

Findings: CRP (p=0.043), fibrinogen (p=0.039) cortisol serum (p=0.001) and S-IgA (p=0.021), concentrations were significant increased immediately after the exercise in the exercise group. A significant relationship was observed between CRP and fibrinogen (r=0. 525, p=0. 048), CRP and S-IgA (r=0. 621, p=0. 022), CRP and cortisol serum (r=0. 712, p=0. 012), fibrinogen and S-IgA (r=0. 638, p=0. 028), cortisol and fibrinogen serum (r=0. 562, p=0. 038), also cortisol and S-IgA (r=0. 734, p=0. 003) in the exercise group.

Discussion & Conclusions: Incremental exercise not only significantly increases inflammatory immune-saliva and stress hormonal markers in non-active pediatrics, but also cardiovascular risk factors in this paediatrics. Rather reveals the close relationships between these indicators that can be effective in predicting cardiovascular risk factors in paediatrics.