Introduction: In recent years, coronary-heart diseases including atherosclerosis have been a large outbreak. These diseases are associated with increasing low density lipoprotein (LDL). Since Peganumharmala and Piper longum plants are used as decreasing the blood lipid profiles in traditional medicine. So, in the present study the effect of ethanolic extracts of Peganumharmala and Piper longumwere was considered on the cholesterol, triglyceride, LDL, HDL, VLDL in mice blood.

Materials & methods: In this study, male NMRI mice were divided into a control group, and three experimental groups. The first treatment group perceived the extract of Peganumharmala with 200 mg/lit concentration(40mg/kg approximately)daily. The second group perceived the extract of Piper longum with 200 mg/lit concentration in drinking water(40mg/kg approximately) daily and the third group perceived daily the combination of both extracts with 200 mg/lit concentration in drinking water (40mg/kg approximately). Treatment period was 30 days. The factors in the serum were measured via Colorimetric method. The obtained data were analyzed by SPSS software (ANOVA and Tukey tests).

Findings: According to data, a significant decreasing (p<0.05) in cholesterol and LDL levels in each of three groups comparing to the control group were observed. Also, the combination of two extract caused the decreasing LDL level toward the extract of each of these plants loneliness, but no significant differences in the level of HDL, triglyceride and calculated VLDL were observed.

Discussion & conclusions: Due to the decreasing of the rate of cholesterol and LDL of the serum in this research, Peganumharmala and Piper longum plants have been probably decreasing LDL and cholesterol.