Introduction: The main purpose of this study was to investigate the effectiveness of cognitive-behavioral based stress management training on depression of MS female patients.

Materials & methods: this study employed a quasi-experimental research method with pre-test posttest, control group and random assignment. The statistical population consists of all female MS patients referring to Iran MS association in 2013. 24 individuals are selected by available sampling among them and were divided into intervention and control group randomly. For measuring independent variable beck’s depression inventory were used.

Findings: The results of analysis of ANCOVA showed that cognitive-behavioral based stress management training has been effective on depression reduction of MS female patients (depression: P<0/01).

Discussion & Conclusion: According to obtained results we believe that cognitive-behavioral based stress management training program has been effective on depression reduction of MS female patients. Thus this training method can be used for target groups and general population as an interventional program.