[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
Publication Ethics::
Peer Review Process::
Indexing Databases::
For Authors::
For Reviewers::
Subscription::
Contact us::
Site Facilities::
::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Citations64373734
h-index2720
i10-index18983

..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Registered in

AWT IMAGE

AWT IMAGE

..
:: Volume 23, Issue 6 (1-2016) ::
Journal of Ilam University of Medical Sciences 2016, 23(6): 10-19 Back to browse issues page
The Expansion of Micro-RNA 21 (miR-21) in the Serum of Patients with Gastric Cancer
Pegah Partow1 , Nahid Masoudian * 2
1- Islamic Azad University, Damghan Branch
2- Islamic Azad University, Damghan Branch , nahidmasoudian@yahoo.com
Abstract:   (8070 Views)

Introduction: MicroRNAs (miRNAs) are new group of regulatory RNAs with approximately 22 nucleotides in length. The miRNAs have important role in human cancers and apparently function as either oncogenes or tumor suppressors. In this study, serum level of miR-21 was determined in patients with gastric adenocarcinoma and its correlation with tumor staging was assessed in the patients, for the first time, in Iran.

Materials & methods: The study was conducted on 40 patients with gastric adenocarcinoma and 40 control subjects who had referred to cancer institute due to gastrointestinal irritation but were diagnosed as healthy on noncancerous. Serum levels of miR‑21 were measured using a quantitative Real-time polymerase chain reaction (qRT-PCR) assay. The correlation of miR‑21  serum level with tumor staging was assessed in the patients.

Results: Serum level of miR‑21 was approximately 3.5 fold higher in patients with gastric adenocarcinoma than control subjects (P<0.0001). Increased level of miR-21 in serum was associated with clinical stages of tumors in the patients (&tau = 0.56, P < 0.01).

Discussion & Conclusions: Given the importance of miR‑21 in the progression of gastric adenocarcinoma and its correlation with clinicopathological factors, the serum level of miR-21 can be served as a new noninvasive diagnostic  biomarker for gastric adenocarcinoma.

Keywords: Gastric adenocarcinoma, MicroRNA, MiR-21
Full-Text [PDF 820 kb]   (7664 Downloads)    
Type of Study: Research | Subject: genetic mlvkly
Received: 2014/10/14 | Accepted: 2014/11/15 | Published: 2015/12/26
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

partow P, masoudian N. The Expansion of Micro-RNA 21 (miR-21) in the Serum of Patients with Gastric Cancer. J. Ilam Uni. Med. Sci. 2016; 23 (6) :10-19
URL: http://sjimu.medilam.ac.ir/article-1-2211-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 23, Issue 6 (1-2016) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.16 seconds with 41 queries by YEKTAWEB 4654