Introduction: Vaspin and Chemerin are the newest hormones secreted from adipose tissues that are responsible for various biological functions, particularly regulating adipose tissues. The purpose of the present study was to investigate the effect of along session of aerobic exercise with different intensities on plasma levels of Vaspin and Chemerin in Female Sprague Dawley Rats.

Materials & methods: Sixty 2-month-old female Sprague Dawley Rats with the average weight of 210 g were purchased. In order to measure the pre-test dependent variables of the study (vaspin and chemerin), blood samples were taken from 15 rats. The rest of the 45 rats were divided into three groups (each group containing 15 rats, the first group with the speed of 12 meters per minute, the second 14m/m and the third 16m/m) and in a session lasting 45 minutes, they were exercised on a special treadmill for rat. The results of the study in each stage {among the 3 training groups, in terms of time (pretest - posttest), the interaction (group×time)} were analyzed via factor analysis of variance.

Findings: The results showed that there was a significant difference among vaspin plasma levels of the three groups (P=0.05) but there was no significant difference in chemerin levels (P=0.63). A significant difference was also observed between pretest– posttest vaspin and chemerin plasma levels (P=0.0001). There was a significant difference among Vaspin levels of the interaction as well (P=0.05), while no significant difference was observed in chemerin levels (P=0.53).

Discussion & Conclusion: Regarding the results and findings of the present study, it can be stated that Adipocytokine response to exercise (in a single session) is not the same and the secretion of each hormone occurs in a certain threshold (of intensity and duration) of physical activity.