Antinociceptive effects of matricaria chamomilla L. ethanolic extract in mice

 Zahra Gholami1, Mansour Amraei1

1Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran

Background and Aim: Chamomile (matricaria chamomilla L.) is a well–known medicinal plants species from the Asreraceas family. Nowadays, chamomile is a highly favored and much used medicinal plant in Folk and traditional medicine through the world, and can therefore be considered as an important medicinal species. Chamomile is an important medicinal plant, whose multitherapeutic cosmetic, and nutritional values have been established through years of Traditional and scientific use and research. chamomile has bee reported to exhibit antiseptic, healding, stimulative ,carminative ,spasmolytic and sedative activities. since chamomile has been Recommended in the literature as a remedy for the alleviating of pain, it was considered Worthwhile to investigate the antinociceptive affects of chamomile ethanolic extract in adult Male NMRI mice.

Materials and Methods: antiniciceptive activity was done using by formalin,hopt plate and writhing tests.the chamoline ethanolic extract (5,10 and 50 mg/kg body wt.)was injectedIntraperitoneally. the control group was administrated with saline.

Result: the results showd that the chamoline ethanolic extract decreased only second phase of formaline induced pain. in hot plate Ethanolic extract exhibited antinociceptive activity against writhing-induced by acetic acid.

Conclusion: the Present data indicated that the plant has antinociceptive effect on mice and the plant should be considered in future therapeutic researches.

 Keywords: chamomile, matricaria chamomilla L., pain,mice