Introduction: Infertility is one of the most painful experiences in women life. With respect to important role of infertility on the women's psychological well being, the purpose of this research was to test a model for the effect of social support on psychological distress considering the mediating role of resilience and problem-oriented coping strategy. Materials and Method: In a correlation study, 95 infertile women that had referred to Fasa public and private medical centers were selected through available sampling. Participants completed Multidimensional Scale of Perceived Social Support (MSPSS), Mental Health Inventory (MHI), Coping Inventory for Stressful Situations( CISS-21) and Connor-Davidson Resilience Scale)CD-RISC(. Fitness of the proposed model was examined through structural equation modeling (SEM), using SPSS-18 and AMOS-18 software packages. The indirect effects were tested using Baron & Kenny (1986) method. Results: Findings indicated that the proposed model fit the data properly. The results also supported the mediating role of resilience and problem-oriented coping strategy in the relationship between social support and psychological distress. Discussion & Conclusion: Considering the findings of the study can be an essential component of any program of infertility-related stress management.