[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Journal Information::
Articles archive::
Publication Ethics::
Peer Review Process::
Indexing Databases::
For Authors::
For Reviewers::
Contact us::
Site Facilities::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019

Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Registered in



:: Volume 22, Issue 4 (9-2014) ::
Journal of Ilam University of Medical Sciences 2014, 22(4): 123-131 Back to browse issues page
The effect of berberine chloride on oxidative stress in hippocampus of streptozotocin-diabetic rats
H Kalalian moghadam * 1, P Baloch nejad mojarad , M Roghani , M Khaksari , P Norouzi , M Fazli , M Ahoei
1- , h.kalalian@gmail.com
Abstract:   (10011 Views)
Background and Objective Diabetes mellitus increases the risk of central nervous system (CNS) disorders such as stroke, seizures, dementia, and cognitive impairment. Berberine, a natural isoquinolne alkaloid, is reported to exhibit beneficial effect in various neurodegenerative and neuropsychiatric disorders. Hyperglycemia through Enzymatic and non-enzymatic processes induces glucose spontaneous oxidation and by stimulating the production of active oxygen and nitrogen lead to oxidative stress. Also overproduction of ROS can cause to DNA and proteins damage and affected function of receptors, enzymes, transport proteins, and inactive antioxidant defense system enzymes or enzymes involved in the repair. Material and Methods: In this study, the male wistar rats (n = 90) were randomly allocated into five groups: control, control berberine-treated (100 mg/kg), diabetic, berberine-treated diabetic (50, 100 mg/kg) groups. Diabetes was induced intraperinoneally STZ administration at the dose of 60mg/kg. Berberine was orally administered at doses of 50 and 100 mg/kg/day one week after STZ injection for a period of 8 weeks. Blood samples were taken from the tail vein 2, 4, 6, 8 weeks after STZ injection to measure blood glucose levels. Lipid peroxidation, nitrite levels and superoxid dismutase activity were evaluated as biomarkers of oxidative stress. Data were analyzed by using Prism-5, one way ANOVA and Tukey tests. RESULTS: Eight weeks after diabetes induction we observed an increase in lipid peroxidation, decreased superoxide dismutase activity, and elevated nitrite levels in the hippocampus of STZ-diabetic rats relative to levels in the control brains. In contrast, chronic treatment with berberine (50 and 100 mg/kg, p.o., once daily) lowered hyperglycemia, oxidative stress, and prevents the up regulation of GFAP in brain of diabetic rats. Conclusion: the present study demonstrates treatment with berberine resulted in an obvious reduction of oxidative stress in hippocampus of STZ -induced diabetic rats
Keywords: Diabetes Mellitus, Berberine, oxidative stress, Cognitive dysfunction, Rat.
Full-Text [PDF 405 kb]   (3481 Downloads)    
Type of Study: Research | Subject: physiology
Received: 2013/11/30 | Accepted: 2014/05/12 | Published: 2014/09/8
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

kalalian moghadam H, baloch nejad mojarad P, roghani M, khaksari M, norouzi P, fazli M et al . The effect of berberine chloride on oxidative stress in hippocampus of streptozotocin-diabetic rats. J. Ilam Uni. Med. Sci. 2014; 22 (4) :123-131
URL: http://sjimu.medilam.ac.ir/article-1-1361-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 22, Issue 4 (9-2014) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.16 seconds with 41 queries by YEKTAWEB 4657