Introduction: Since low adjustment is one of the main problems prisoners struggling with and considered to be one of the reasons for their tendency toward dangerous behaviors, this study was aimed at investigating the effect of desensitization by eye movements and reprocessing on enhancement of social, affective and health adjustment of prisoners. Method of study: This study was designed based on experimental method and by pretest and posttest model with control group. A sample of 40 individuals was taken (based on the type of their crimes) from prisoners in Ardebil's central jail with jail sentences as long as 4 months using stratified random sampling method. Rosenberg Self-Esteem Scale and Bel adjustment questionnaire were used to collect data which was completed in both pretest and posttest by experimental and control groups. Treatment of desensitization with eye movements and reprocessing was conducted during four sessions on experimental group and during which control group was not involved. . Data was analyzed using covariance analysis test. Findings: the results from this investigation indicated that the average grades for social, affective and health adjustment in experimental group were significantly higher than those in control group (P<0.001). Conclusion: treatment of desensitization by eye movements and reprocessing were effective on enhancing the adjustment of male prisoners. Therefore jails' psychologists can play a substantial role in enhancement of the adjustment of these people by teaching this short term treatment method and implementing it on sentenced people upon their entrance to jail.