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:: Volume 22, Issue 4 (9-2014) ::
Journal of Ilam University of Medical Sciences 2014, 22(4): 74-82 Back to browse issues page
Effect of Zingiber officinale on analgesia induced by Morphine in adult male Wistar rats
A Gomar * 1, N Mirazi , M Gomar
1- , gomar.ucla@yahoo.com
Abstract:   (7005 Views)
Aim: There are some reports in traditional medicine concerning the anti-inflammatory effect of Zingiber officinale. In the present study with the aim of decreasing analgesic dose of Morphine, analgesic effect of different doses of ginger hydroethanolic extract alone and associated with Morphine were evaluated by Tail-Flick in rats. Material and Methods: Animals were divided randomly into six groups (n=6). 30min after treatment, Rats were placed into restrainer and then transferred into the Tail-Flick apparatus. Results were expressed as mean±SEM. The data were analyzed by one-way ANOVA and Tukey’s test. Statistical significance was considered at P<0.05. Results: The Data have shown that the ginger extract relieved pain in tail-flick test (P˂0.001). Also this result was shown the extract combined with morphine (P˂0.05). Conclusion: Our data show that hydroethanolic extract of ginger has an important antinociceptive effect that possibly through the intervention of the central and peripheral systems involved in pain pathways can lead to decrease pain in rats. On the basis the results obtained in this study, it could be suggested that the ginger extract potentiates morphine increase antinociceptive effect and this means that the opioid system may be involved in the analgesic effect of this plant extract. Also due to the effects of morphine, Combination Extract and Morphine can decrease doses of Morphine, therefore can be able decrease side effect of this drug.
Keywords: Zingiber officinale, ginger, pain, rat, Morphine.
Full-Text [PDF 465 kb]   (2435 Downloads)    
Type of Study: Research | Subject: animal physiology
Received: 2013/11/16 | Accepted: 2014/05/12 | Published: 2014/09/3
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gomar A, mirazi N, gomar M. Effect of Zingiber officinale on analgesia induced by Morphine in adult male Wistar rats. J. Ilam Uni. Med. Sci. 2014; 22 (4) :74-82
URL: http://sjimu.medilam.ac.ir/article-1-1329-en.html

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Volume 22, Issue 4 (9-2014) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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