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:: Volume 21, Issue 4 (10-2013) ::
Journal of Ilam University of Medical Sciences 2013, 21(4): 191-198 Back to browse issues page
Frequency of Celiac Disease in Patients with Diarrhea Predominant Irritable Bowel Syndrome Referred to Gastroenterology Clinics in Ilam During 2008 to 2012
A Jafri haidarlo , Ar Mahmodi , M Yasemi , A Baziar , S Ehsan bakhsh , M Rashid begi * 1
1- , miladrashidbeygi@yahoo.com
Abstract:   (12216 Views)
Introduction: Several studies showed inc-reased prevalence of celiac disease (CD) in irritable bowel syndrome (IBS) how-ever, the evidence is conflicting and often dose not propose to explor CD in the patients. This study aimed to investigate the preval-ence of CD in patients with diarrhea pred-ominant IBS. Materials & Methods: The present research was a descriptive cross-sectional study that performed on 1000 IBS patients with diarrhea- predominant clinical picture refe-rred to a gastroenterology clinic in Ilam during 2008 to 2012. Blood samples were taken from all patients to assay IgA to tiss-ue transglutaminase (IgA anti tTG) by ELI-SA method. Biopsies samples from the sec-ond part of duodenum in the patients were provided by endoscopiy and sent to patholy clinic for histopathological evaluation and final diagnosis. Finding: The mean age of men and women participating in the study were 11.41±29.59 and 11.73±28.42 years, respectively. More than half of the participants were female (50.3%). The mean titer of IgA anti tTG in men and women with IBS were 17.17±5.25 and 25.4±7.22 U/mL, respectively. 76 IBS patients had high antibody titers (IgA anti tTG ≤10), among which 41 patients were female and 35 patients were male. Among the patients with high antibody titer, 57 subjects (75%) had CD (based on histo-logical findings). The prevalence of CD was 5.7% among the patients with IBS. Discussion & Conclusion: The results of this study suggested that all IBS patients with diarrhea-predominant clinical picture are needed to examine for the presence of CD. The diagnostic approach presented in this study may also be useful in the asses-ssment of CD.
Keywords: celiac disease, irritable bowel syndrome, anti body
Full-Text [PDF 418 kb]   (9883 Downloads)    
Type of Study: Research | Subject: Internal operations( nursing )
Received: 2013/10/14 | Accepted: 2013/10/20 | Published: 2013/10/20
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jafri haidarlo A, mahmodi A, yasemi M, baziar A, ehsan bakhsh S, rashid begi M. Frequency of Celiac Disease in Patients with Diarrhea Predominant Irritable Bowel Syndrome Referred to Gastroenterology Clinics in Ilam During 2008 to 2012. J. Ilam Uni. Med. Sci. 2013; 21 (4) :191-198
URL: http://sjimu.medilam.ac.ir/article-1-1269-en.html

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Volume 21, Issue 4 (10-2013) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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