[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Journal Information::
Articles archive::
Publication Ethics::
Peer Review Process::
Indexing Databases::
For Authors::
For Reviewers::
Contact us::
Site Facilities::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019

Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Registered in



:: Volume 17, Issue 1 (4-2009) ::
Journal of Ilam University of Medical Sciences 2009, 17(1): 19-24 Back to browse issues page
Effectiveness of Valerian As A Complementary Medicineon Bipolar Mood Disorders
Mojgan Jariani * , Mandana Saki
Abstract:   (12889 Views)
Introduction: Nowadays, pharmacotherapy and psychotherapy are the main treatments for bipolar mood disorders. Using complementary and alternative medicine has increased over the past decade. Valerian is a herb commonly marketed for treatment of insomnia, anxiety and depression however, positive results have also been reported in curing bipolar disorders. The mechanism of valerian’s effectiveness is the same as benzodiazepines affecting on GABA-A receptor. Materials & Methods: In a clinical trial setting, a sample was selected from patients aging between 18 and 75 years who met the diagnostic criteria for bipolar mood disorder according to the DSMVTR and whose diagnoses were confirmed by clinical examinations. Eighty patients with a current diagnosis of bipolar disorder participated in a 8-week, parallel-group, double-blind addition valerian to ongoing mood stabilizing therapy. All the participants had a Mania Rating Scale score of 12 or higher and received conventional mood stabilizers treatment for at least 3 months. Eighty participants were selected and upon obtaining written consent were randomly divided into two equal case and control groups. Findings: Among the patients receiving valerian, severity and frequency of Mania rating scale score decreased from 62/93(SD=15/21), 67/3 at pre-treatment to 41/38 (SD=11/94), 51/8 at the first month and even further to 32/9(SD=9/57), 39/7 at the end of the second month. In the control group, severity and frequency of Mania rating scale score at the end of the first and second months of treatment were 61/82(SD=12/04),71/22, 56/05 (SD=10/43),64/2, respectively. Using the Friedman test, we observed no significant difference in the depression and function levels before and after the 2-months treatment between the case and control groups .Highly significant benefits of the addition of the valerian compared with the control group were found by 8th week of treatment. Discussion & Conclusion: Considering the observations achieved from this study, it is concluded that valerian augments mood stabilizer can be used as an adjunct treatment in bipolar mood
Keywords: bipolar mood disorder, complementary medicine, valerian
Full-Text [PDF 327 kb]   (3815 Downloads)    
Type of Study: Research | Subject: General
Received: 2009/08/5 | Accepted: 2015/04/20 | Published: 2015/04/20
Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

jariani M, saki M. Effectiveness of Valerian As A Complementary Medicineon Bipolar Mood Disorders. J. Ilam Uni. Med. Sci. 2009; 17 (1) :19-24
URL: http://sjimu.medilam.ac.ir/article-1-102-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 17, Issue 1 (4-2009) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.17 seconds with 41 queries by YEKTAWEB 4642