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Showing 2 results for Vitamin D
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Volume 16, Issue 2 (7-2008)
Abstract
Abstract
Introduction: Vitamin D3 deficiency seems to be associated with the induction and development of patients infected with M tuberculosis to tuberculosis disease.
Materials & methods: In this case- control study, 45 patients with tuberculosis beside another 45 people without any TB history were selected. All the patients and the control group were compared with each other for vitamin D3 level by RIA (radioimmunoassay) method. Then, results were analyzed by t-test and analyze & variance in spss11/1.
Findings: The mean and SD of vitamin D3 level were (M=12.25, SD=9.98) and
(M= 24.68, SD=19.22) (P=0(among patients and the control group, respectively.
39(86.66%) patients and 26(57.77%) control members had a vitamin D3 level of below 20ng/ml. 28(62.22%) patients had tuberculosis in warm seasons. (summer P=0/007)& (fall, P=0/02) & (winter, P=0/08).
Conclusion: There was a significant association between previous vitamin D3 deficiency and tuberculosis. Further more, tuberculosis frequently occurred in warm seasons
Zainulabden Zainulabden Ali Abdulrahim1, Amir Ghanbarpour Nosrati, Mousa Khalafi,
Volume 33, Issue 2 (5-2025)
Abstract
Introduction: Brain-derived neurotrophic factor (BDNF) has beneficial effects on non-neuronal tissues, particularly cardiovascular cells, but its effects on the BDNF-TrkB pathway in heart tissue have not been studied. Therefore, the aim of the study was to investigate the effect of high-intensity interval training (HIIT) and vitamin D supplementation (VitD) on the protein levels of cardiac BDNF-TrkB in rats fed with a high-fat and high-carbohydrate diet.
Materials & Methods: Sprague Dawley rats were divided into normal diet (ND), high fat and high carbohydrate (HFD+HC), high fat and high carbohydrate with HIIT (HFD+HC+HIIT), high fat and high carbohydrate with VitD (HFD+HC+VitD), and high fat and high carbohydrate with HIIT and VitD (HFD+HC+HII+VitD). Protein levels of BDNF and TrkB were assessed using Western blotting. Independent t-tests, one-way ANOVA, Tukey's test, and SPSS V.26 were used to analyze the data.
Results: Consumption of HFD+HC resulted in a decrease in protein levels of BDNF and TrkB in the heart compared to ND (p<0.05). On the contrary, HIIT and VitD only resulted in a non-significant increase in protein levels of BDNF and TrkB in the heart compared to the HFD+HC group. However, the combination of HIIT and VitD resulted in a significant and non-significant increase in the protein levels of TrkB (P=0.03) and BDNF (P=0.06) compared to the HFD+HC group.
Conclusion: HIIT+VD, by increasing cardiac BDNF and TrkB, may prevent the deleterious effects of high-fat and high-carbohydrate diets on this cardiac signaling, while each of these interventions alone has little effect on cardiac BDNF and TrkB.
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