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Showing 20 results for Human
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Volume 14, Issue 4 (1-2007)
Abstract
Abstract
Introduction: Human serum Albumin (HSA) is a single strand protein that plays a major role in the maintenance of plasma oncotic pressure. Surface of this protein is covered with unneutralized negative charges and has an important role in the transfer of some drugs , fatty acids , cations and hormones in the blood .
Materials & Methods: HAS (Hexadesyl pridinium bromide ) was purchased from Sigma company and the other reagents were recieved from Merck Co. UsingPhosphate buffer in pH=7 for all experiments through CD- spectrophotometer (model Jasco) secondary structure changes in the protein were observed. The ligand binding of HSA- HPB interaction was studied by fluke potentiaometer. HSA concentration in all experiments was 0.2 mg/ml.
Results: HSA CD spectra in the far – UV region were obtained at 370C and 420C . The binding isotherms and also scadchard curves for HAS-HPB interaction at 370C and 420C were drawn and discussed .
Conclusion: Rising temperature from 370C up to 420C proved a considerable effect on the structural aspects of HSA. HSA- HPB interaction depends on the temperature so the affinity of HSA for HPB binding reduces as temperature increases to 420C from 370C . Therefore, the amounts of negative charges on the surface of HSA at the 420C are less then those at 370C and leads to the decrement of blood oncotic pressure. This effect expresses the considerable effect of HSA on the moderation of fever on the body.
... ,
Volume 16, Issue 3 (10-2008)
Abstract
Abstract
Introduction: Aluminum is the third most abundant element in the earth's crust .It plays a role in several neurodegenerative conditions including Alzheimer's disease. In this study, we investigated the effects of aluminum on human embryonic astrocytes.
Materials & methods: In this experimental study, we applied MTT techniques to investigate the effects of 3,9, and 12 days exposure to aluminum on astrocyte viability . Then, we used immunocytochemical techniques to identify apoptotic gene expression changes induced by aluminum. We used Stata software to analyze the data.
Findings: Our results showed that 3-days exposure to 1 and 1.5 mM caused a reduction in astrocytes viability, (P<0.01, P<0.03). Low levels of aluminum (500 and 100 µM) needed long-term exposure to become toxic to astrocytes, (9 days for 500 and 12 days for 100 µM) (P=0.000). Aluminum didn't show any effects on apoptotic gene expression.
Conclusion: Long-term exposure, even to low levels of aluminum, was toxic for human embryonic astrocytes, but it seems that aluminum does not alter apoptotic gene expression.
, , , , , , ,
Volume 18, Issue 3 (10-2010)
Abstract
Introduction: Human respiratory syncytial virus (HRSV) is the most important viral agent of acute respiratory infection in children less than 5 years age worldwide. HRSV is responsible for 50% brochiolitis and 25% pneumonia in infants. There are limited data of HRSV genotypes from developing countries. The aim of this study was to investigate HRSV genotypes in 2007 and 2009 in Iran.
Materials & Methods: 72 and 107 respiratory samples were collected from children less than 5 years of age with acute respiratory infection in 2007and 2009, respectively, whom were tested for G glycoprotein gene of HRSV by RT-PCR.
Findings: Of the 72 respiratory samples tested in 2007, 14 samples (19,44%) were positive for HRSV and fell on three genotypes: 12 strains in GA2, 1 strain in GA1 , and 1strain in GA5. Whereas, of the 107 respiratory samples tested in 2009, 24 samples (22,24%) were positive that 16 (67%) belonged to subgroup A genotypes: 15 strains in GA1, and 1Strain in GA2, whereas, 8 (33%) clustered in genotype BA in subgroup B.
Discussion & Conclusion: This study revealed that multiple genotypes of HRSV were cocirculated on years 2007 and 2009 in Iran. Also our results showed that subgroup A strains were more prevalent than subgroup B viruses, GA2 and GA1 genotypes were predominant genotypes on years 2007 and 2009, respectively.
, , ,
Volume 19, Issue 2 (7-2011)
Abstract
Introduction: The biceps brachii muscle belongs to the flexor group of muscles in the arm. It is the only flexor of the arm crossing the shoulder joint as well as the elbow joint, thereby acting on both the joints. The biceps brachii muscle is known to show variations in the number of papers.
Materials & Methods: The routine dissection of the brachial region of a man cadaver in the dissection hall of medical college at Zabol University of Medical Sciences.
Findings: An accessory head of biceps brachii muscle has been observed unilaterally on the right upper limb of male cadaver. Whereas the two heads of the biceps brachii muscles arose from their usual position, but the accessory head arose from deep fascia of the deltoid muscle and the pectoralis major muscle on the arm. The accessory head was found to fuse with the common belly of the muscle well before the bicipital tendon and its aponeurosis. This accessory head was supplied by a branch of the musculocutaneous nerves. This supernumerary head was supplied by the brachial vessels.
Discussion & Conclusion: Different positions for accessory head of biceps brachii muscle is observed. Being aware of such variations is of importance both for anatomists and clinicians, especially for plastic surgeons in flap surgery of arms.
A Ahmadzadeh, M Feizie, M Habibi Rezaie,
Volume 19, Issue 4 (1-2012)
Abstract
Introductioni Glycation is a non enzymatic
reaction initiated by the primary addition of
sugar to the amino groups of proteins.In the
early stage of glycation, the synthesis of
intermediates leading to formation of
Amadori compounds occurs. In the late
stage, advanced glycation end product
(AGE)is irrevesibly formed after a complex
cascade of reactions. Glycation also affect
diabetes-related complications
physiological aging and neurodegenerative
diseases such as alzeimers.
Materials & Methodsi In this study, HSA
incubation with glucose and different
concentration of papaverine for 42 days at
37°C. as well as HSA incubation alone
(control sample), with glucose(glycated
sample)were treated respectively under the
same conditions. After 42 days, the samples
by use of circular dichroism, fluorescence
and UV spectroscopy were investigated.
Findingsi HSA glycation increases alon
with rising of papaverine concentration.
Samples containing papaverine showed
more changes in secondary structure free
amino groups and AGE fluorescence in
relation to glycated and control samples.
Discussion & Conclusion: In glycated
helix and sheet a 5.7% decrease and 3.1%
increase were seen in comparison to the
control respectively. Glycated showed
14.2% fluorescence more than the control.
Free lys number in glycated showed 8%
less in relation to the control. All this cases
showed more changes in samples which
contained papaverine. HSA absorb in
presence of papaverine showed that
papaverine cause more lys contact with
sugar and an increase in glycation.
M Zamaninan Azodi , Ar Ardeshiry Lajimi , M , Rezaei Tavirani, M , Rezaei Tavirani, R Khodarahmi,
Volume 20, Issue 4 (2-2013)
Abstract
Introduction: Since bacteria became resistant to some types of antibiotics, it is prominent to find more reliable sources against them. In view of the fact that plants have been shown verity of biological eff-ects, they could be promising substitutions. Inasmuch as Scrophularia has shown differ-rent biological properties such as antimic-robial, antitumor and anti-inflammatory activities, its effect on Escherichia coli has been evaluated.
Material & Methods: Antibiotic effects of both filtered and nonfiltered extract of Scro-phularia striata on Escherichia coli as gram-negative bacterium were evaluated by spectrophotometery method. Simultaneou-sly tetracycline was used as a positive control at different concentrations. In addi-tion, MTT assay was applied for cell surv-ival determination.
Findings: Our findings indicate that conc-entrations between 1 to 20 µg/ml of the extract have significant antibiotic activities there is no noticeable difference between filtered and nonfiltered antibiotic activities of this extract. Moreover, this effect is totally different from inducing properties of the extract.
Discussion & Conclusion: In conclusion, 5 µg/ml of the extract has a significant antibiotic activity whereas there is not such an effect on fibroblast cells. In view of the fact that this concentration of the extract has a potential antibiotic activity accomp-anied with considerable low side effects on human cells, Scrophularia striata extract can be regard as a potential antibiotic agent in the future.
M Zamanian Azodi, Ar Ardashiri Lajimi, N Ahmadi, S Gilanchi, N Abbasi, A Hematian,
Volume 20, Issue 5 (3-2013)
Abstract
Introduction: Bacteria have become resistant to some kinds of antibiotics. Therefore, more reliable sources are vital to be examined. Some types of herbals have been shown promising for therapeutic points, so they could be applied in the field of medicine. Scrophularia consist of different biological activities such as antimicrobial, antitumor and anti-inflammatory activities. Consequently, its effect on Staphylococcus aureus has been studied.
Material & Methods: Antibiotic effects of both filtered and non-filtered extract of Scrophularia striata on Staphylococcus aureus as gram-positive bacterium were evaluated by spectrophotometer. Simultaneously tetracycline was used as a positive control at different concentrations. In addition, MTT assay was applied for cell survival determination.
Findings: Our findings point out that concentration between 1 to 20 µg/ml of the extract has remarkable antibiotic activities. In addition to this, there is no obvious difference between filtered and non-filtered antibiotic activities of this extract. On the other hand, fibroblast cells show absolutely different response when treated with the same extract.
Discussion & Conclusion: It can be concluded that, the Scrophularia striata aqueous extract has significant antibiotic activity and with less side effects than tetracycline. As a result, Scrophularia striata extract can be regard as a probable antibiotic agent in the future studies additionally, more investigation is needed for evaluating in vivo outcomes, and the effective materials of the extract component
P Vasoghi, N Ahmadi, M Shahani, E Bahadori Monfared, M Azizi,
Volume 21, Issue 7 (2-2014)
Abstract
Introduction: Human serum albumin with its singular structure acts as a carrier mo-lecule that can attach to a variety of sub-stances. Any structural or functional chan-ges in albumin are accompanied with unde-sirable outcomes. In the present research, attachment of some ligands such as det-ergents (DTAB) and sugars (glucose) to albumin were evaluated at temperatures 27°C and 42°C.
Materials & Methods: Tris-buffer solusion for albumin with a pH close to the pH of body was prepared. To denature albumin, hydrochloric acid was used. UV spectero-photometric technique was applied to eval-uate denaturation process.
Findings: With increment of DTAB conc-entration the maximum optical absorption of albumin decreased. Glucose concent-ration at 400mg/dl level caused a profound change in the optical absorption of albumin that might affect the structure of the mo-lecule.
Discussion & Conclusion: Glucose elevate-on has deleterious effects and deteriorates the function of many molecules in blood. The effects may exert on hormones, drug transportation, necessary ions and elements
M Alikhani, M Jamalian, A Omrani, H Barkati, A Babaee Haidarabadi, A Eimani, M Delpasanf, F Ostad Jafar, A Noormohamadi,
Volume 21, Issue 7 (2-2014)
Abstract
Introduction: In the period of optimization of talent, organizations search for creative and innovative approaches to upgrade their competitive advantages and in this turbulent and complicate environment, only human resource could be useful for organizations. The purpose of this study was to investigate the relationship between the components of human capital and the components of lea-rning organizations among faculty members of the Imam Khomeini's hospital in 2011.
Materials & Methods: This research was conducted through a cross-sectional and descriptive fashion. The society under study consisted of 227 faculty members working at Imam Khomeini hospital complex. Data were collected by means of a questionnaire that its validity and reliability were assured by expert’s corroboration and alpha Cron-bach coefficient (0.94), respectively. The data were analyzed via descriptive and ana-lytical statistics (Spearman correlation coefficient) by SPSS software.
Findings: The results revealed a moderate learning organization status based on the opinions of faculty member at Imam Kho-meini hospital complex. There was a signi-ficant relationship between the human capital and learning organization comp-onents (P<0.005).
Discussion & Conclusion: Regarding to the presence of a significant positive relations-hip between the human capitals and learn-ing organization components, the necessity of applying this method as a new and effi-cient theory in management and health syst-em would be inevitable
M Zamanian Azodi, S Gilanchi, P Amini Gram, S Hajhosaini, K Haghani,
Volume 21, Issue 7 (2-2014)
Abstract
Introduction: Given the importance of human serum albumin, evaluation of the protein is invaluable. One of the characteristics of the protein is to create ligand bindings. The trait was assessed by application of the surfactant, sodium dodecyl sulfate (SDS), as a ligand under normal and pathologic temperatures and normal and diabetic concentration of glucose.
Material & Methods: UV spectroscopy was the method used in this experiment. Human Serum albumin was evaluated in the presence of different concentrations of glucose and the following conditions: SDS at the conce-ntrations, 2, 1.5, 1, and 0.5mM as indices for ligand binding assay, and normal and fever temperatures.
Findings: The high temperature 42°C and different concentrations of glucose created structural changes in albumin. This effect was more significant at 400 mg/dl conce-ntration of glucose.
Discussion & Conclusion: Human Serum Albumin structure was highly affected by increment of temperate which was more evident in diabetic condition.
Mostafa Nemati,
Volume 23, Issue 6 (1-2016)
Abstract
Introduction: The contamination of poultry carcasses in slaughter house according to the number of poultry and systems has a risk for human health. In this research some Gram- negative bacteria were isolated from alimentary canal. In addition, serotyping of Salmonella was performed.
Materials & methods: Four hundred alimentary canal specimens from 80 industrial poultry farms (5 chickens per farm) were sampled and sent to Ilam University laboratory. Gram-negative bacteria were isolated and identified by mean of standard biochemical tests. The serotyping of salmonella isolates was carried out by the Razi Vaccine and Serum Research Institute, Karaj, Iran. Sequence analyses for a representative selection of Gram-negative bacteria were performed commercially by Macrogen, South Korea.
Findings: Out of 80 flocks, species of some genera including Proteus, Escherichia, Enterobacter and Salmonella were isolated form 75 (94 %), 40 (50%), 30 (38%) and 5 (6%) flocks, respectively. The results showed that three salmonellae were identified as Salmonella O7 (Group C1), one O8 (Group C2) and the other as O9 (Group D).
Discussion & Conclusions: The high presence of the bacteria in poultry’s alimentary tract in slaughter house immediately before they were slaughtered may be a pose for human health hazards. Thus, based on the findings of this study poultry’s alimentary tract bacteria should be considered as a potential source of contamination for the public health.
Meghdad Kazemi, Mohsen Jalilian, Mehrdad Kazemi, Mohamadamin Rashidi,
Volume 25, Issue 4 (11-2017)
Abstract
Introduction: Human resource is the most important factor in organizational development. This study aimed to evaluate the effect of education, job displacement, performance evaluation and job achievement on human resource development.
Materials & methods: Two hundred employees working in Ilam University of medical science were participated in a cross-sectional study. Study instrument was self-report questionnaire to measuring human resource performance. Study data were analyzed by SPSS.21 and independent sample t-test and Pearson correlation were conducted.
Findings: Findings showed that the mean of age, work experience and delivering training to new comers in staff employees were significantly higher than Pardis employees (P<0.05). Pearson results showed positive and significant correlation between the human resources performance in staff employees (P <0.05). Education (2/48± 0.98) and Performance Evaluation (2/41±1/33) have highest mean score among the factors affecting the human resources development in Pardis and staff employees, respectively.
Discussion & conclusions: Application of appropriate education and assessment strategies can have significant impact on human resources performance and development.
Alireza Shirmohammadi , Liela Raeisi , Masoud Raei Dahaghi ,
Volume 25, Issue 6 (3-2018)
Abstract
Introduction: The observance of human rights requirements as a general rule in concluding international agreements, such as the WTO agreements, is necessary and, accordingly, a commitment to guarantee the right to access basic medicines as one of the titles and examples of the right to health, which has a meaningful relationship. It also has the right to live which is inevitable for governments.
Materials & Methods: The present study uses a descriptive-analytical method to determine the provisions of the International Covenant on Economic, Social, and Cultural Rights on the Right to Access to Essential Medicines as Human Rights, which can be considered as one of the examples of support for pharmaceutical innovations. The patent that is protected by the World Trade Organization's Trips agreement as a trade-mark of intellectual property rights is protected by the definition of private law.
Findings: Based on the provisions of the Trips Agreement on Patents, including Articles 27 and 28, the holder holds the exclusive intellectual property right to manufacture, use, supply for sale, and sale or import, which can challenge the access to medicines. The underlying cause and the increase in the cost of such drugs, and this in particular, makes it difficult for developed and less developed countries to respect the commitment to support and enforce access to essential medicines.
Discussion & Conclusions: In addition to the provisions of the Trips Agreement on limited exceptions and compulsory licenses, the approval of the Doha Summit Declaration on the Trips and Public Health Agreements, as well as the issuance of the Trips Council Decision on the implementation of the provisions of paragraph 6 of this Declaration, are considered as solutions. It has been considered that this Declaration has actually resolved the conflict between the provisions of this agreement and the human rights requirements.
اقا Mohammad Aidi, خانم Zarifeh Sadehmiri,
Volume 26, Issue 5 (11-2018)
Abstract
Introduction: The most important feature of smart organizations in the 21st century is their emphasis of on knowledge and information. This study aimed to investigate the level of intellectual capital in Medical University of Ilam, Iran, in 1394.
Materials & Methods: This descriptive survey was conducted on the employees working at Medical University of Ilam. The population consisted of 330 employees, 178 of whom were randomly selected as the sample using Cochran’s method. The main instrument for data collection was Bontis’s scale of intellectual capital with 25 items and high level of validity and reliability. The analysis of data was preformed through Kolmogrov-Smirnov method, the parametric tests of t-test, Pearson correlation, and regression in SPSS software.
Findings: The findings of the current study indicated that intellectual capital and knowledge management and their sub scales in Medical University of Ilam were at an acceptable level. The results showed that knowledge management could positively and significantly affect intellectual capital in the organizations.
Discussion & Conclusions: According to the findings of this study, it can be concluded that organizational creativity and innovation can be developed if intellectual properties and knowledge management are set as the primary concern of an organization.
Mohammad Shokrzadeh, Abbas Mohammadpour, Mona Modanloo, Narges Kargar Darabi, Faezeh Khajavi,
Volume 27, Issue 2 (6-2019)
Abstract
Introduction: Medicinal plants, such as flaxseeds play an important role in the health of individuals and communities. Regarding the phytochemical properties of flaxseed, this study aimed to investigate the hydroalcoholic effects of this plant on the genetic toxicity of cyclophosphamide in peripheral blood lymphocytes.
Materials & Methods: The flaxseed extract was initially prepared by maceration using ethanol solvent in two rounds. After one hour of incubation with different concentrations, the blood samples were incubated with 750µ M in a bain-marie at 37° C for 24 h. To evaluate the production of micronucleus in dual nuclear lymphocytes suppressed in cytokines, the slides were prepared and evaluated using light microscopy. The data were analyzed in SPSS software and the mean values were compared using Tukey's test and.
Ethics code: 30.96.3.1002
Findings: The incubation of blood samples with cyclophosphamide leads to induced additional genotoxicity in lymphocytes. Moreover, flaxseed extract pretreatment significantly reduced the micronucleus frequency (P<0.0001). In addition, the results showed the effective role of flaxseed extract as a protective agent in reducing the genotoxicity of the pesticide cyclophosphamide.
Discussion & Conclusions: According to the obtained results, flaxseed is a potent antigenotoxic agent against cyclophosphamide-induced DNA damage. Since the flaxseed extract does not have cytotoxic effects, it can be used as a protective agent against the toxic effects of cyclophosphamide.
Azim Hasanbaigi, Javad Abdi,
Volume 27, Issue 3 (8-2019)
Abstract
Introduction: An organization is a network of departments and individuals that improves the performance of the organization through establishing synergy in the meaningful and purposeful communication between departments and individuals. Therefore, effective organizational communication is required to achieve organizational goals. In order to enhance organizational communication in Ilam University of Medical Sciences, the current article investigated the influential factors affecting this communication.
Materials & Methods: This descriptive correlational study utilized a researcher-made questionnaire for data collection. The study population included 170 participants selected out of 476 statistical populations (all the staff of Ilam University of Medical Sciences) using simple random sampling. Data were analyzed in SPSS software (version 20) using multiple regression and path analysis.
Findings: Based on the results, organizational factor was found to exert a more profound effect on organizational communication in this university with a coefficient of .639, as compared to human factor with a coefficient of 0.258; in other words, the organizational factor is more effective in the enhancement of organizational communication.
Discussion & Conclusions: According to the results of this study, Ilam University of Medical Sciences should be looking for an appropriate model of organizational communication and according to its position, design a desirable model in which organizational factors affecting organizational communication should pay more attention.
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Reza Jafari Nodoushan, Ali Sadri Esfahani, Tahmasb Akhtar, Khalil Taherzadeh Chenani,
Volume 29, Issue 4 (10-2021)
Abstract
Introduction: Human error plays a significant role in the occurrence of industrial accidents. Displacement and unloading operations are operations in which the occurrence of human error may lead to plenty of human and financial losses. The present study aimed to investigate the possibility of human error occurrence in overhead crane operators in a Steel Company in Hormozgan, Iran.
Material & Methods: This cross-sectional and descriptive study was conducted using the Standardized Plant Analysis Risk-Human Reliability Analysis (SPAR-H) technique. In this study, the job tasks of overhead crane operators were firstly analyzed using the hierarchical task analysis (HTA) technique. Subsequently, the probability of human error in job tasks was assessed using the SPAR-H technique.
(Ethic code: IR.ACECR.JDM.REC.1399.005)
Findings: Generally, five main tasks and 16 sub-tasks have been analyzed in this study. The highest probability of error was related to the three sub-tasks of longitudinal motion, transverse motion, and high and low motion (0.3975). The lowest probability of error was under the duty of recording shift reports, transmitting information orally, and writing (0.05). The results of this study clearly showed the effect of interdependence on increasing the probability of error occurrence.
Discussion & Conclusion: Based on the results of the present study, some preventive measures were proposed to reduce the possibility of human error, including identifying and controlling job stressors, correcting the ergonomic status of crane cabins, preparing work instructions, as well as training and monitoring their proper implementation.
Fatemeh Javani Jouni, Jaber Zafari, Elaheh Shams, Parviz Abdolmaleki, Ali Asghar Rastegari,
Volume 29, Issue 6 (12-2021)
Abstract
Introduction: Cancer is the leading cause of death in most countries. There are several methods used to treat cancer. Doxorubicin is one of the most important chemotherapy drugs that has several side effects, such as infertility, hyperuricemia, neuropathy, and cardiomyopathy. This study aimed to evaluate the anti-cancer effects of Naja naja oxiana in comparison with doxorubicin in Hela (Human cervical cancer) and HFF (Human foreskin fibroblast) cell line.
Material & Methods: Hela and normal fibroblast cancer cell lines were exposed to different concentrations (1, 10, 50, 100, and 500 μg/ml) of snake venom and doxorubicin. The MTT method was used to evaluate the IC50 (Inhibitory Concentration) for toxins and drugs. Finally, the results were analyzed using SPSS software (version 19).
Findings: The results show that with increasing concentration and time of treatment with snake venom and doxorubicin, the percentage of Hela and fibroblasts living cells decreases. The highest decrease in the percentage of the viable cells was observed in the Hela cancer cell line treated with a concentration of 500 μg/ml snake venom for 48 h.
Discussion & Conclusion: Snake venom can have a significant inhibitory effect on the percentage of living Hela cancer cells in comparison with doxorubicin.
Mohammad Motaharinia, Mahdieh Sadeghpour, Monir Shalbafan,
Volume 30, Issue 2 (6-2022)
Abstract
Introduction: Drugs are mainly delivered to the target tissues by plasma proteins, such as human serum albumin, in the human body. Practical information about the thermodynamic parameters of drugs and their stability can be obtained using simulation methods, such as molecular docking.
Material & Methods: This study, investigated the molecular docking of human serum albumin with fluorouracil anticancer drug. Moreover, partial charges on serum albumin protein atoms and fluorouracil atoms were calculated in this study. The best configuration was also searched using the Lamarckian genetic algorithm. The dimensions of the grid maps were selected to be about 40 * 40 * 40 angstroms with a distance of 0.375 angstroms. The number of genetic algorithms and the number of studies were adjusted to about 100 and 2.5 million, respectively. In the end, the best performed interaction configurations with the least amount of free energy were selected. Ligplot and VMD graphic software were used to view the performed docking.
Findings: In the best model, fluorouracil is able to bind to the human serum albumin protein HSA four hydrogen bonds via nitrogen and oxygen atoms with two amino acids tyrosine, one amino acid histidine and one amino acid arginine. The estimation of the free bond energies (kcal/mol) for the best model was -5.1. Negative Gibbs free energy values (ΔG °) indicated a spontaneous process, and a constant binding value (Ka ≈ 109 L • mol-1) demonstrated the optimal biological distribution of the drug in the blood plasma.
Discussion & Conclusion: The docking study of the proposed models shows that fluorouracil has an aliphatic ring and hydrophobic fractions and therefore it has a high ability to form hydrophobic interactions with major amino acids at the active site of serum albumin protein.
Farnaz Soltani, Ali Sharifzadeh,
Volume 32, Issue 2 (5-2024)
Abstract
Introduction: Gastric ulcer caused by Helicobacter pylori is one of the common diseases in humans, which is transmitted through eating and drinking. This bacterium has the ability to settle in the stomach of some animal species, including dogs and cats. In some cases, the carrier animals are the source of infection for humans. The present study aimed to assess the amount of Helicobacter pylori infection in people having contact with pets, and the pets themselves in Isfahan.
Material & Methods: To dis end, 115 fecal samples were taken from the owners of domestic dogs and cats and microbial culture and polymerase chain reaction tests were performed to identify Helicobacter pylori.
Results: The results indicated that 36% of domestic dog owners, 80% of domestic cat owners, and 8% of dogs themselves were infected. In addition, no positive cases of infection were observed in cats. In the chi square test (Pearson's test), the infection of domestic dogs and cats showed a significant relationship with the infection of their owners (P<0.05).
Discussion & Conclusion: The relatively significant infection of dogs to Helicobacter pylori and the possibility of its transmission to humans makes the observation of health care more important more than ever.
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