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Introduction: Promotion and improvement of children's health is a part of the global obje-ctives of primary health care. This study inve-stigated psychometric characteristics of quality of life in elementary students of Kashan city in 2011. Materials & Methods: This cross-sectional study was performed on 400 elementary stud-ents (Grades 3 to 5) who were selected through random sampling. Content validity of the Per-sian version of the PedsQL 4.0 was checked and tested through the process of translating interview with children 9-12 years (N = 30) and their parents (N = 30) in the primary schools of the Kashan city. Construct validity and reliability of the PedsQL on the sample of elementary children in Kashan (N = 400) and their parents (N = 400) were tested. Criterion-related validity (concurrent) was estimated through investigating the correlation between child self-report of quality of life and parent proxy-report of quality of life along with demographic variables. Data were analyzed by using the SPSS V.18, and LISREL8.8 soft-wares. Findings: Totally, content validity of PedsQL was 0.84 and of the four subscales, physical, emotional, social, and school performances w-ere 0.80, 0.86, 0.83, and 0.88, respectively. Construct validity was good. (RMSEA = 0.047, NFI=0.99, GFI =1.00, P =0.15, df = 2, χ2 =3.77). All inquiries showed a moderate to higher than 0.40 loading over for four factors, physical, emotional, social, and school perfo-rmances. The correlation coefficient between the PedsQL and its four subscales were ace-ptable (r>0.7). The PedsQL had a good internal consistency (α =0.82). Cronbach alpha coefficients range of different categories of the mentioned tool was from 0.65 to 0.77. There was a significant relationship between PedsQL of children and parents and, also the demo-graphic characteristics of the population under study. Discusion & Conclusion: The findings indic-ated the suitability of psychometric properties of the Persian version of PedsQL to measure the quality of life in elementary students. Sch-ool administrators and health system profess-sionals can use this study to design guidelines for creating a healthy environment and devel-opment of the programs of health-based edu-cation in order to improve the quality of life and health of students