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Showing 3 results for Vascular Endothelial Growth Factor
Exir Vizvari, Parvvin Farzanegi, Phd Hajar Abaszade Sourati, Volume 27, Issue 1 (4-2019)
Abstract
Introduction: One of the consequences of diabetes is an angiogenesis disorder. Physical activity plays an important role in the improvement of this disorder. Therefore, the aim of this study was to investigate the effect of moderate aerobic training on serum levels of angiogenic (NO, VEGF) and angiostatic (ES) factors in women with type 2 diabetes.
Materials & Methods: In this randomized clinical trial with pretest-posttest design, 28 women with type 2 diabetes, age range of 40-50 years , and mean weight of 70.58 ± 2.11 were randomly assigned into control and exercise groups (n=14). The training intervention included 8 weeks of moderate aerobic exercises (60-70% HR max) for 60 min each session and 5 times per week. Metabolic parameters and serum levels of NO, VEGF and ES were evaluated before and 48 h after the exercise protocol. Statistical analysis was performed using repeated measure ANOVA in SPSS software (Version 24) (P<0.05).
Finding: Eight weeks of aerobic training in women with type 2 diabetes caused a significant increase in NO (P=0.09), VEGF (P=0.014), insulin sensitivity (P=0.01), and HDL (P=0.040). However, there was no significant increase in ES(P=0.103). Moreover a significant decrease was observed in weight, body mass index, fasting blood glucose, triglyceride, A1C (P=0.01), low density lipoprotein (P=0.029), and cholesterol (P=0.012), compared to the control group.
Discussion & Conclusions: Mild regular aerobic exercise seems to have a protective effect against vascular problems due to the improvement of serum levels of angiogenesis and metabolic parameters in patients with type 2 diabetes.
Elham Vosadi, Farhad Gholami, Marzieh Amirsalary, Volume 30, Issue 4 (10-2022)
Abstract
Introduction: During exercise, angiogenesis occurs in active skeletal muscle; however, little is known about potential mechanisms for improving this adaptation. This study aimed to investigate a period of interval training on chemokine gene expression and its effect on vascular endothelial growth factors in male adult rats.
Material & Methods: In this study, 24 rats were divided into three groups (n=8 in each): high-intensity training (HIT), low-intensity training (LIT), and control groups. HIT and LIT groups were trained for eight weeks (five days per week). The exercise program in the HIT group consisted of running on a treadmill for 8 min with 85-90% VO2max intensity and 2 min with 50-60% VO2max intensity. The LIT group exercise program consisted of running on a treadmill for 8 min with 55-60% VO2max intensity and 2 min with 45-50% VO2max intensity. The control group had no training. The expression of chemokine and vascular endothelial growth factor genes was measured in soleus muscle. The data were analyzed using one-way ANOVA and Tukey post hoc test. Statistical differences were considered significant at P<0.05.
(Ethic code: 141/370299)
Findings: The results of this study, showed that the expression levels of chemokine and vascular endothelial growth factor gene in the HIT group were significantly higher than that in the control group (P=0.01, P=0.04), while the levels of chemokine and vascular endothelial growth factor in the LIT group were not significantly different from those in the control group (P=0.2, P=0.1).
Discussion & Conclusion: According to the results of the present study, it seems that high-intensity exercises can be more effective than low-intensity exercises in increasing angiogenesis caused by the increase of chemokine that in turn depends on vascular endothelial growth factor levels.
Masoud Moradi, Abdolhamid Habibi, Mohammadreza Tabande, Saeed Shakerian, Volume 33, Issue 1 (3-2025)
Abstract
Introduction: Inflammatory and autoimmune diseases like multiple sclerosis are linked to immune system gene activation and oxidative stress, with betaine demonstrating anti-inflammatory effects by controlling these gene signaling pathways. The aim of the present study was to investigate the effects of water exercises with betaine supplementation on vascular endothelial growth factor and oxidative stress indices in the cerebellum of rats with multiple sclerosis.
Materials & Methods: A study involving 28 adult male rats, aged 12 weeks, was conducted to study MS. MS was induced using cuprizone for 6 weeks, and the rats were divided into 7 groups. Swimming exercises were performed daily for 6 weeks, and betaine was administered daily in drinking water for 6 weeks. Cerebellar tissue was isolated and endothelial growth factor, malondialdehyde, and superoxide dismutase were measured using ELISA kits. Data analysis was done using SPSS V.22, with one-way analysis of variance and LSD post hoc test at a P<0.05 level.
Results: MS disease causes a decrease in endothelial growth factor and superoxide dismutase levels. The lesion + exercise + betaine group showed a significant increase in the endothelial growth factor, a significant decrease in the malondialdehyde and, a significant increase in the superoxide dismutase variable compared to the lesion group (p ≤ 0.001).
Conclusion: Swimming exercises and betaine supplementation can enhance vascular growth factor indices and oxidative stress in individuals with MS by increasing endothelial growth factors and superoxide dismutase.
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