Introduction: Candidal vulvovaginitis occurs in female genital by the over growth of candida especially candida albicans. This infection may be resistant to therapy and occasionally becomes chronic. In some patients this form of infection is recurrent. Candida species are the most important factors in development of fungal infection in human beings and animals. According to the daily increase of drug resistance, attempts are important for providing anti-fungal and anti-microbial drugs. With the increasing consumption of medical plants for medical treatment, this topic of complementary medicine found a unique place. This study compares the concentration effects of Cichorium intybusL. and Matricaria chamomilla L.  hydroalcoholic extract and the mixed with Nystatin on the isolated Candida albicans from Vaginal Candidiasis and standard under in vitro conditions. 
 
Materials & Methods: This experimental study assessed the antifungal effects of two plant extracts on candida albicans. Cichorium intybus L and Matricaria chamomilla L. were selected based on the previous researches and traditional usages.   C.Albicans was cultured on sabouraud dexterose agar containing chloramphenicol. On each plate, one plant extract disc, one nystatin disc (as positive control), and one blank disc (as negative controls) were placed. The mean diameter of non-growth halo around each plant extract was compared with the mean diameter of non-growth halo of positive control discs after 24 hours. Data was analysed by ANOVA statistical test (P<0.05).
 
Findings: There was a significant difference between the diameter of non-growth halo around the plant extracts and Nystatin discs. The diameter of non-growth halo in nystation discs (30 mm) was more than that for Matricaria chamomilla L. discs (21 mm). Non-growth halo in discs (28 mm) nystation were also more than Cichorium intybus L. discs (17 mm) (p<0.05). As well as the diameter of non-growth halo in Combination Matricaria chamomilla L. and Nystatin discs(47 mm) was more than that for nystatin Matricaria chamomilla L. discs(21 mm) and the diameter of non-growth halo in Combination Cichorium intybusL, and Nystatin discs(45 mm) was more than that for nystatin Cichorium intybusL discs(17 mm).
 
Discussion & Conclusions: Cichorium intybusL and Matricaria chamomilla L.  exhibited antifungal effects on C. Albincans But the effect of Matricaria chamomilla L.  on the lack of growth of Candida Albicans strains was greater than that in Cichorium intybusL.
 

Introduction: The resistance of opportunistic fungal strains has been on a growing trend in the recent years. The toxicity of antimicrobial drugs, development of fungal resistance, and incidence of drug interactions account for the consideration of new drug combinations against fungi. Regarding this, the present study was conducted to perform an in vitro investigation on the effect of paramagnetic iron oxide nanoparticles and magnetic water on Fusarium oxysporum.
 
Materials and Methods: The synthesis of paramagnetic iron oxide nanoparticles was conducted in Islamic Azad University, Falavarjan Branch, Falavarjan, Iran, using the co-precipitation method. The antifungal effects of paramagnetic iron oxide nanoparticles and the impact of magnetic water with an intensity of 0.1 Tesla on Fusarium oxysporum were investigated using pur plate technique. Accordingly, the percentage of Fusarium oxysporum growth inhibition was determined.
 
Findings: The results of X-ray diffraction and electron microscopy showed that iron oxide nanoparticles had a diameter of 20-25 nm with a cubic shape. Based on the results of pur plate technique, 0.1 Tesla magnetic water reduced the diameter of Fusarium oxysporum colonies by more than 49.64% on all days. In addition, the iron oxide nanoparticles at a concentration of 500 ppm inhibited the diameter of the fungal colony by more than 30% on all days. Furthermore, the combination of iron oxide nanoparticles at a concentration of 500 ppm with 0.1 Tesla magnetic water inhibited the growth of fungal colonies by more than 50%. Therefore, the combined method exerted the greatest synergistic impact on reducing the diameter of the fungal colony. Similar to ketoconazole (concentration of 0.003 mg/ml), on the first day, iron oxide nanoparticles with a concentration of 500 ppm inhibited fungal growth.
However, on the twelfth day, 0.1 Tesla magnetic water had a better performance, compared to ketoconazole as a conventional antifungal drug.

Conclusion: As the findings indicated, paramagnetic iron oxide nanoparticles with a diameter of 20-25 nm alone and in combination with 0.1 Tesla magnetic water had magnetic antifungal activity against Fusarium oxysporum.