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Showing 2 results for Anticancer

Atena Vafayi Malek, Ehsan Karimi, Ehsan Oskoueian,
Volume 29, Issue 3 (8-2021)
Abstract

Introduction: Medicinal plants are among the most important products in agriculture and medicine. The usefulness and cheapness, environmental friendliness, and limited side effects of medicinal plants have increased the rate of use of these plants in recent years. Plant extracts, such as cloves, have long been used in medicine, perfumery, and as additives in cooking. This study aimed to evaluate and compare the antioxidant, antibacterial, and anti-cancer effects of clove essential oil and nanoemulsion.
 
Materials & Methods: Antioxidant activity of essential oil and clove nanoemulsion by measuring the inhibitory activity of DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS radicals (2 and 2-azino-bis-3-ethyl benzothiazoline-6-sulfonic acid) was measured in this study. The evaluation of antibacterial and bactericidal properties of essential oil and clove nanoemulsion was conducted by culture medium and suspension of four pathogenic bacteria of gram-positive, including Staphylococcus aureus and Bacillus subtilis, and gram-negative bacteria, including Escherichia coli and Pseudomonas aeruginosa, followed by the measurement of the diameter of the growth inhibition zone. In addition, the effects of cytotoxicity of clove essential oil and nanoemulsion on different concentrations of 15.6, 31.2, 62.5, 125, and 250 μg/ml on MCF7 cancer cells were evaluated by MTT staining.
 
Findings: Clove nanoemulsion, compared to essential oil, had good antioxidant potential and a significant effect on free radical scavenging. The rates of free radical scavenging (IC50) of clove essential oil nanoemulsion were obtained at 67.29 and 78.39 μg/ml measured by DPPH and ABTS methods, respectively. Clove essential oil and nanoemulsion had an inhibitory effect on both groups of gram-positive and gram-negative bacteria tested in this study. The toxicity test also showed a greater effect of clove nanoemulsion in killing breast cancer cells, compared to the clove essential oil.
 
Discussions & Conclusions: The results of this in vitro study indicate the antioxidant and anti-cancer effects of clove nanoemulsion, compared to essential oil, which can be used to prevent and treat many diseases associated with the development of reactive oxygen species.
Sanaz Salek, Elham Moazamian, Afshin Mohammadi Bardbori Mohammadi Bardbori, Seyedeh Azra Shamsdin,
Volume 32, Issue 6 (12-2024)
Abstract

Introduction:  The efficacy of 5-fluorouracil (5-FU) as a chemotherapy drug for colorectal cancer (CRC) is well-established. However, due to resistance to 5-FU and its associated complications, it is necessary to search for adjuvant therapies against CRC. Considering the anticancer potential of probiotic metabolites, this study assessed the anticancer effects of potential probiotic strains isolated from mule milk, camel milk, and the standard probiotic strain Lactobacillus rhamnosus GG (LGG), used alone and in combination with 5-FU, against the human colon cancer cell line (HT-29) and normal human embryonic kidney (HEK-293).
Materials & Methods: Biochemical and molecular techniques were implemented to identify the strains isolated from mule and camel milk. The MTT assay was also employed to assess the anticancer effects of the probiotic strains of Lactobacillus isolated from mule milk and camel milk and of LGG, used alone and in combination with 5-FU, on the two cell lines HT-29 and HEK-293. The data were statistically analyzed using analysis of variance, and significant differences between means were assessed using Tukey's post hoc test. Minitab 20 software performed all statistical calculations in the level of significance less than 0.05.
Results: The results demonstrated the potential probiotic properties of all the studied Lactobacillus strains. The combination of cell extracts from Lactobacillus strains with 5-FU effectively reduced the viability of HT-29 cells.  Nonetheless, this combination can reduce the cytotoxic effects of 5-FU on the viability of HEK-293 cells, thereby increasing their viability.
Conclusion: These results point to the possibility of using Lactobacillus strain cell extracts as an adjuvant therapy for cancer treatment


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مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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