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educational media has been considered to provide information and skills necessary for healthy decision-making and community h-ealth promotion. Therefore, evaluation of health education media is essential to impr-ove and promote the quality of health edu-cation. Materials & Methods: The study samples included all produced media in all Iran me-dical universities, offices, and centers affili-ated to the ministry of health during 2005 to 2010. All of the media under investigation were categorized by type and topic through software that was designed for this purpose and then, they were analyzed. Findings: Results of this study showed that 16.44% of the media produced in the com-municable diseases subject and 13.33% produced in the non-communicable subject. Pamphlet had the highest percentage of the media (34.91%) and Multimedia had the lowest percentage (0.0001%). Study findi-ngs also showed that the non-print media comprised only 6% of the mass media. Discussion & Conclusion: Given the imp-ortant role of educational media, especially new media in Increasing the knowledge and community empowerment, it is recomm-ended to paid more attention to the neces-sity of new media to inform health educa-tors.

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Introduction: Regarding the chronic nature of epilepsy and resistance to chemical drugs, herbal medicine has received remarkable interest. This study investiagted the anticonvulsant effects of hydro-alcoholic extract of Salix Alba leaves on PTZ-induced seizure in male mice.
Material & Methods: In total, 56 albino male mice weighing 20-25 g were divided randomly into seven groups (8 animals per group) including negative (saline), positive (Phenobarbital) control, and five groups which received different doses of hydro-alcoholic extract of Salix Alba leaves. After 45 min, all groups received the convulsant pentylene tetrazole, and the onset time of myoclonic, tonic-clonic seizures, and the 24-hour mortality rate were measured.
(Ethic code: IR.GUMS.REC.1394.566)
Findings: The extract significantly delayed the onset of myoclonic and tonic-clonic seizures at a dose of 100 mg/kg (P<0.01) and for other doses (P<0.001), compared to the control group. Moreover, the extract decreased the 24-h death. This was significant at 1000 mg/kg (P<0.001), as well as 300, 500, and 800 mg/kg (P<0.05), compared to the control group.
Discussion & Conclusion: It seems that the hydro-alcoholic extract of Salix Alba leaves has a significant diminishing effect on PTZ-induced seizures in male mice which is due to its anti-inflammatory and anti-oxidant effects.

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Introduction: Alzheimer's disease is a common progressive neurogenerative disease that leads to dementia and destruction of brain cells, especially in areas related to learning and memory such as the hippocampus. The role of the Arc gene in synaptic flexibility and memory consolidation has been proven and its expression is strongly influenced by neuronal activity. The aim of this study was to investigate the effect of Lactobacillus fermentum on the expression of Arc (effective in synaptic flexibility and memory consolidation) and CREB (effective in stabilizing synaptic changes during learning) genes, involved in the memory of Alzheimer's rats.
Material & ethods: In this study that was conducted in 2019, 30 male Wistar rats were divided into 5 groups (control, Alzheimer and 3 groups as treatment). In the treatment groups, simultaneously with induction of Alzheimer by stereotaxic method with streptozotocin, supernatant of Lactobacillus fermentum PTCC 1744 in MRS broth with doses of 10⁸, 10⁷, and 10⁶ cfu/ml was injected intraperitoneally for 21 days. After RNA extraction from hippocampus samples, cDNA was synthesized and the expression of the genes was evaluated by real-time PCR and LinReg PCR software.
Findings: The data showed an increase in gene expression of Arc and CREB in the treatment groups with a dose of 10⁶ cfu/ml compared to the Alzheimer's group and the difference was significant (P <0.001).
Discussion & conclusion: Extracellular compounds of L. fermentum may inhibit the progression of neuronal lesions due to their antioxidant and anti-inflammatory effects and may be effective in improving Alzheimer's.