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Introduction: The purpose of this study was to examine the contribution of coping strat-egies against mental disorders among patie-nts with diabetes. Materials & Methods: For the study, 50 patients with diabetes mellitus (18 insulin-dependent diabetes mellitus and 32 non-insulin-dependent diabetes mellitus patient-s) from the mental health center of Firooz-abad city (located in south west of Iran) were selected using convenience sampling. All subjects completed 3 questionnaires: demographic characteristics, Coping Strate-gies, and Symptom Checklist -90 –Revised (SCL-90-R). Data were analyzed using Pea-rson correlation, stepwise multiple regressi-on and MANOVA. Findings: There was a high rate of mental disorders among the patients and insulin-dependent diabetes mellitus had higher ave-rage scores in comparison with non-insulin-dependent diabetes mellitus. No significant differences were observed between the two groups for the coping strategies question-nnaire. There was a significant relationship between emotion-focused and less useful coping strategies with mental disorders (P<0.5). Regression analysis revealed a significant role of coping strategies for mental disorders in patients with diabetes (P<0.5). Discussion & Conclusion: Coping strate-gies had a significant contribution in predi-cting mental disorders in patients with dia-betes.