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Background: The aim of this research was to examine the effect of mindfulness cognitive therapy on blood pressure sistolic and diastilic of male patients with blood pressure in Golestan Hospital of Ahvaz. Materials and Methods: This research was a semi-experimental study with pre-test, post-test and control group. The study community was male patients with essential blood pressure who referred to Golestan Hospital of Ahvaz. The research sample was selected by in-reach sampling method. Thus, 32 out of 40 patients were selected based on semi-structured clinical interview and with regard to inclusion criteria. These samples were randomly divided into experimental and control groups. In this research, Blood Pressure Measuring Devices, were used. The experimental intervention performed on experimental group consisted of 8 sessions of mindfulness cognitive therapy, while the subjects in control group were on a waiting list. At last, a post-test was performed. For data analysis, multivariate analysis of covariance (MANCOVA) was used. Results: The results showed that there was a significant difference, between the two groups in terms of blood pressure sistolic and diastolic. Conclusion: Therefore, it can be said that mindfulness cognitive therapy was effective in reducing essential blood pressure sistolic and diastolic in experimental group in comparison with control group.