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Introduction: Human vagina represents a dynamic ecosystem dominated by certain species of Lactobacillus. These microorganisms restrict the growth of pathogens by using properties of steric exclusion and inhibitory substance production. Women with reduced numbers of lactobacilli usually experience serious complications including bacterial and fungal infections. External application of these medicines causes appropriate growth of Lactobacillus which consequently reduces the infections. The aim of this research is to compare the application of Povidone iodine and Clotrimazol cream on vaginal infections. The aim of this research is comparison of treatment with Povidone-iodine and clotrimazole on Materials & Methods: Vaginal discharge of women referring to Rasht’s Alzahra hospital was transferred to lab. Samples were plated on sabouraud dextrose agar medium for isolation of fungi. Specific tests were done for the study of Candida albicans. Also, different dilution of povidone-iodine and clotrimazole were tested on samples. Findings: According to results of culture medium, clotrimazole had better effect on Candida albicans in comparison with povidone-iodine. Discussion & Conclusion: Due to the side effects and unpleasant picture of povidoneiodine usage, clotrimazole is suitable against Candida albicans infections.