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Introduction: Stroke is the third cause of death in the world. Ischemic stroke can be observed in the 85 to 90% of strokes. In the condition, cerebral blood flow due to the blockage of blood vessels is interrupted and a very complex process, literally called the cascade of ischemic, begins to occur at the cellular and tissue level, which eventually leads to tissue damage and the expression of ischemic stroke. Approaches in this area are weak and a further knowledge of the molecular mechanisms contributing to more effective diagnosis and treatment. Of the valuable tools for the understanding of molecular processes involved in ischemic stroke is proteomics method that provides us a snapshot of the proteins expressed at the cellular or tissue level, and can give us valuable information for the characteriza-tion of its biological processes. Materials & Methods: In this study, the data from human brain proteome changes in ischemic stroke using two-dimensional gel electrophoresis and mass spectrometry were analyzed by DAVID program. The lists of genes with altered protein expression were obtained from the article “the proteome of human brain after ischemic stroke”. Findings were analyzed by the DAVID bio-informatics software. The association betw-een ischemic stroke genes and other dise-ases, stroke clustering of proteins based on biological processes and intra cellular sites and molecular functions of the genes was performed via "GO" database. Findings: Of 39 genes involved in ischemic stroke, totally four biological pathways ch-art were obtained which were associated with central nervous system diseases such as Parkinson, Alzheimer and Huntington. Most of the proteins were located in mitochondria and more significantly invol-ved in the response to oxidative stress, apoptosis and necrosis processes. Discussion & Conclusion: The data from two-dimensional gel electrophoresis-based proteomics experiments are important for understanding of the processes that occur during ischemic stroke. Proteins identific-ation may be used as treatment targets or as biological markers for diagnostic and prog-nostic purposes in the management of stro-ke.

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Introduction: One of the human emotional feelings is anxiety and if this feeling becomes severe, it may lead to undesirable results. A general estimation of mean score of anxiety has not reported in Iranian society up to now. This study aims at estimating the mean score of anxiety in Iran by the systematic review and meta-analysis method.
 
Materials and methods: Searching was conducted using the keywords of Anxiety,Concerns,Stress,Depression and Iran in foreign databases of Pub med, Scopus, ISI, and google scholar as well as domestic ones including SID, Medlib, Magiran and Iran medex. The data were analyzed using the meta-analysis method (the random effects model). The disharmony of the studies was investigated using the I² index. The data were analyzed by the STATA Ver.11 software.
 
Findings: Of 174 articles under investigation with the sample of 29839 people during years 1999 to 2016, mean score and standard deviation of anxiety was estimated to be 29.46 (Confidence interval 95%: 24.74 to 34.18). Mean score of Anxiety was estimated to be 25.96 in women, 24.00 in men, 13.13 in married people and 13.34 in singles. Mean score of apparent anxiety 45.81, hidden anxiety 45.13, stress 10.51 and depression 11.37 were estimated as well.
 
Discussion & conclusions: According to result of the study, mean score of anxiety is high in Iran. Furthermore, it is more in women than in men and there is not a significant difference between the married people and singles.