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In modern implantolotology there are several indications for laser. Different laser systems can be applied in soft and hard tissues surgery. In this review, literature was searched for application of laser in second-stage surgery of implants, treatment of peri-implant bony defects, removal of peri-implant hyperplastic tissues, and the preparation of bone cavities for implant placement. This report describes the application of different laser systems in treatment of peri-implantitis. Our study evaluated in vitro, animal and clinical examinations. The exact selection of the appropriate laser system was dependent on the evaluation of recent literature, the effect of laser on implant surface and, the level of temperatures rise during laser application. Two major advantage of laser which are reduction in bacteriae and the cutting effects associated with the coagulation properties of the lasers are the main reasons for laser application in the treatment of peri-implant lesions and can improve the prognosis of ailing implants.