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Showing 3 results for Yazdani
Faramarz Yazdani, Javad Vakili, Mahnaz Omidi, Abdolhossein Taheri Kalani,
Volume 24, Issue 5 (12-2016)
Abstract
Introduction: Using nutritional supplements is proposed to avoid the stresses-induced by physical activity, delayed fatigue and maintenance of performance during competition. The aim of this study was to explore the effect of combined supplement Neurobion on Creatine Kinase (CK) and Lactate Dehydrogenase (LDH) enzymes levels following a session of exhaustive exercise in amateur men boxers.
Materials & methods: Twelve men boxer with an average age of19.1±2 years, weight 71.3±6.2 kg and percentage of body fat 8.9±0.7 participated in this study. In two consecutive weeks, they consumed Neurobion supplement and placebo (distilled water) into5 ml ampoule and then carried out exhaustive exercise boxing. Exercise implemented with fists swiping to punch bag in 3 rounds of 3 minute with 1 minute rest intervals between rounds with maximum intensity and competitive. To measure the levels of LDH and CK induced by muscle cell damage, blood samples were taken in four stages before, immediately, and 2and6hours after exercise.
Findings: The results showed that consuming combination of vitamin Neurobion had a significant effect on serum levels of LDH and CK in different stages of exercise (p=0.001).With intake supplement, the amounts of CK in2and6hours, and LDH in the immediately after the exercise, compared with placebo group had a significant reduction (p<0.05).
Discussion & conclusions: It is concluded that, using combination of vitamin supplement Neurobion by maintaining molecular structure of cells and sarcomere, as well as muscle cell membrane integrity, cause reduced amounts of LDH and CK enzymes in the amateur boxers after exhaustive exercise.
Jalil Derakhshan, Adibeh Abdi, Somayeh Yazdani, Mohmmad Babamiri, Sardar Saiedi, Yaser Khaledi,
Volume 26, Issue 6 (12-2018)
Abstract
Introduction: Low-frequency noise, even at low levels, is annoying and affects the physiological function of individuals. Some individual differences, such as sensitivity to noise, can reduce or increase the effect of noise on physiological parameters. The purpose of this study was to investigate the effect of individual sensitivity on physiological parameters in the presence of low-frequency noise.
Materials & Methods: This is an interventional study. 120 subjects were selected through targeted sampling (60 high sensitivity and 60 low sensitivity). By simulating the real environment of each person, they were exposed to 50, 60, and 70 dB of noise. Before and after exposure, the mean body temperature, skin temperature, heart rate, blood pressure, and oxygen content was measured and recorded. Data were analyzed using the SPSS20 software package, independent t-test, and paired T-test.
Code of ethics: IR.umsha.REC.1395.457
Findings: The results showed that low-frequency noise negatively affects physiological parameters and increases physiological parameters by increasing the noise level from 50 to 70 dB (P<0.05). Investigating the combined effect of individual sensitivity to noise and gender showed that physiological parameters are more affected in women and people with high sensitivity (P<0.05).
Discussion & Conclusions: Considering that high blood pressure is closely related to cardiovascular disease, the use of people who are more tolerant to noise (low sensitivity) in areas where exposure to noise is higher than the safe limit can prevent cardiac complications.
Maedeh Yazdani Dizicheh , Hossein Azizi , Dariush Gholami , Amir Khaki ,
Volume 32, Issue 4 (9-2024)
Abstract
Introduction: Spermatogenesis is the primary process of sperm production occuring in seminiferous tubules. Spermatogonial stem cells (SSCs) have the ability for self-renewal, differentiation, and the transmission of genetic information to subsequent generations. KLF4 and POU5F1 are transcription factors expressed in a wide range of tissues and play key roles in such processes as apoptosis, differentiation, proliferation, and cellular development. The present study aimed to assess the expression levels of KLF4 and POU5F1 genes in mouse embryonic stem cells (mESCs), spermatogonial stem cells (SSCs), embryonic-like stem cells (ES-like), and testicular cells, and identify the signaling pathways associated with them in the process of spermatogenesis.
Materials & Methods: In this experimental study, spermatogonial cells were extracted from mouse testes using enzymatic digestion method and cultured in GSC medium containing FGF, EGF, and GDNF. Thereafter, the expression of KLF4 and POU5F1 genes was examined in mESCs, SSCs, ES-like, and testicular cells was investigated using immunocytochemistry, immunohistochemistry, and reverse transcription-polymerase chain reaction methods, and protein-protein interactions and signaling pathways were evaluated using bioinformatics methods.
Results: The KLF4 and POU5F1 genes exhibited positive expression in ES-like cells and testicular cells. The assessment of KLF4 mRNA and POU5F1 mRNA expression levels demonstrated that KLF4 expression is higher in mESCs and ES-like cells compared to other cells, while POU5F1 expression is higher in SSCs. Both KLF4 and POU5F1 are considered essential and powerful genes that share a common class and function.
Conclusion: The findings of this study indicated that KLF4 and POU5F1 play crucial roles in the proper development of sperm and are present in various types of cells, including mESCs, SSCs, ES-like cells, and testicular cells. These factors are key components of sexual stem cells and contribute to stem cell proliferation, making them potential diagnostic markers for these cell lines.
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