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Showing 14 results for Valizadeh
A Valizadeh , N Sadeghifard , M Zolfaghary, A Maleki, S Ghafourian, P ,
Volume 20, Issue 2 (8-2012)
Abstract
Introduction: Some Pseudomonas aerugin-osa strains produce Extended Spectrum Beta Lactamase which causes resistance to cephalosporins such as cefteriaxon, cefota-xim, ceftazidim and also monobactams such as azteronam. Over expression of efflux pumps including MexAB-OPRM is a factors which play an important role in resistance of Pseudomonas aeruginosa strains to antibiotics.
Materials & Methods: In order to detect the mutation frequency in PA3721 gene, 50 isolates of Pseudomonas aeruginosa isola-ted from urinary tract infection in Emam Khomeini Hospital of Ilam and Milad Hospital in Tehran were studied. The isolates were confirmed by biochemical methods and the Extended Spectrum Beta Lactamase were screened by disk diffusion method. Phenotypic confirmatory test by combined disk was utilized for confirma-tion of ESBLs. In next step, ESBLs genes as well as mutation in frequency PA3721 gene in producing and non producing ESBLs Pseudomonas aeruginosa strains were identified by PCR method.
Findings: In this study, 50 isolates were studied, including 18 isolates from Milad Hospital and the rest from Ilam Hospitals. In Milad Hospital, ESBLs genes for PER, PSE and VEB and in Ilam Hospitals ESBL gene for OxA-10 were detected. In Ilam samples including 32 isolates of which 17 samples produced ESBLs, all carried oxA-10 gene and 8 isolates (47/05%) were positive for mutation in PA3721 gene.
Discussion & Conclusion: According to the results, Meropenem was more effective against Pseudomonas aeruginosa isolates in in vitro condition. The results also showed that nearly half of oxA-10 producing Pse-udomonas aeruginosa isolates carry nalC gene.
A Ashrafi Hafez, Mr Fakor Ziba, A Babaee Haidar Abadi, F Hosaini, E Razmposh, Z Gharlipour, K Dashdebi, R Valizadeh,
Volume 21, Issue 4 (10-2013)
Abstract
Introduction: Commonly, the origin of drug use in adults comes from youth. This is one of the most important social problems that not only endanger the public health but it also lead to moral and ethical decay of individuals. The aim of this study was to investigate the prevalence of psychoactive substances use and its risk factors in Shiraz University and Shiraz University of Med-ical Sciences.
Materials & Methods: In the descriptive- analytical study, 640 students from the schools of Shiraz University and Shiraz University of Medical Sciences were selected based on a random cluster sampling method. Data were collected by self-completion anonymous questionnaires. After data collection, analysis was performed using SPSS software.
Findings: The rate of psychoactive subst-ances use among the students of Shiraz University of Medical Sciences and Shiraz University were 10.8% and 9.2%, resp-ectively, that their difference was not significant (p = 0.498). The rate of psy-choactive substances use among men was more than of women (25% vs. 19%) and the history of use was more in married students than the single ones (19.5% vs. 8.7%). The students of Shiraz University versus Shiraz University of Medical Sciences used more alcohol (17.7% vs. 9.4%), drugs (9.8% vs. 3.3%) and smoking (21.5% vs. 17.5%) and these differences were statistically significant.
Discussion & Conclusion: This study indicated the necessity of planning and preventive interventional strategies to reduce drug use among students and thereupon promoting their health.
Z Rasaee, N Sadeghifard, Mr Zolfaghari, S Ghaforian, P Shakib, A Valizadeh,
Volume 21, Issue 5 (10-2013)
Abstract
Introduction: Pseudomonas aeruginosa (P.aeruginosa) is one of the opportunistic pathogens in hospital that afflicts patients with burning damages, respiratory diseases, cystic fibrosis, bacterinemia, septicemia and many of other prevalent infections. P.aer-uginosa has two types of cyclic PAPI such as PAPI-1(108 kb) and PAPI-2 (11kb). The big island, namely, PAPI-1 has an important role in virulence, evolution and development of pathogenic process of the bacteria. Many cellular contamination capa-bilities of the bacterium including chronic infections in people with cystic fibrosis are arisen from function of the gene. The aim of this study was to evaluate the frequency of PAPI-1 gene in clinical isolates of P.aeruginosa.
Materials & Methods: Clinical isolates of P.aeruginosa were identified by traditional methods. After extraction of genomic DNA, the existence of PAPI-1 coding gene was confirmed by using polymerase chain reaction (PCR).
Findings: Of the isolates under study, 17 samples (35.41%) contained PAPI-1gene. Among 29 samples of urinary tract origin, 9 samples (31.03%) contained PAPI-1 gene and from 19 samples of burn injuries, 8 samples (42.1%) contained PAPI-1. This big island of P.aeruginosa, namely, PAPI-1, was equally existed in burning and urinary infection samples.
Discussion & Conclusion: Results of the present study indicated that the big island, PAPI-1, in PA14 strain of P.aeruginosa has a very wide role in bacterial infections. These results revealed the active presence of this big island in the development of pathogenicity and bacterial infection capa-bility by P.aeruginosa.
R Valizadeh, F Kavari Zadeh, M Yasemi , M R Yasemi , M Rashidbeigi, H Tavan,
Volume 22, Issue 6 (1-2015)
Abstract
Introduction: The General Health Qu-estionnaire (GHQ) is used to detect mental disorders. The aim of this study was to determine the psychometric properties of the 28 questions version of the General Health Questionnaire (GHQ -28).
Materials & Methods: In a methodolo-gical study, 118 secondary school stud-ents in the city of Ilam were selected through random sampling method. In this study, the 28 questions version of the General Health Questionnaire was used. Construct validity was used to determine the validity and internal consistency (Cronbach's alpha coeffi-cient) was used to determine the relia-bility.
Finding: The GHQ is composed of six factors, The first factor is headache with the score of (14.22 ± 2.88), the second factor is insomnia with the score of (12.42 ± 2.48), the third factor is joy of life with the score of (10.45 ± 2.09), the fourth factor is health with the score of (10.387 ± 2.08), the fifth factor is feelings of worthlessness with the score of (9.96 ± 1.99) and the sixth factor is suicide attempt with the score of (8.42 ± 1.68), respectively. Cronbach's alpha coefficient for the scale was found to be 69%.
Discussion & Conclusion: The first fa-ctor of GHQ included questions, the second factor included questions, the third factor included questions, the fou-rth factor included questions, the fifth factor included questions and the sixth factor included questions.
K Sayemiri, R Valizadeh, M Yasemi, M Rashidbeigi, Mr Yasemi, H Payman,
Volume 22, Issue 6 (1-2015)
Abstract
Introduction: Given the more complicating of the designing of researches, implement-tation and interpretation of medical research and developing of evidence-based medicine amended the knowledge of biostatistics in order to understand the results of other rese-arches and designing new research for fac-ulty members and physician. This study ai-med to compare the knowledge, attitude and confidence of faculty members, physic-cian and medical students towards biostat-istics at the Ilam University of Medical Sciences in 2011.
Material & Methods: Data was collected using a standard questionnaire that contain-ed the parts, demographic data, attitude and confidence to biostatistics and questions ab-out knowledge of participants towards bio-statistics. The base of attitude and knowle-dge score was considered 100 and that of the confidence score was 20. Data were an-alyzed using SPSS 16 and ANOVA and χ2 test.
Finding: Overall, 91.3% and 80% had pas-
sed epidemiology and biostatistics courses, respectively. 46.8% of the participants were medical students, 31.9% physicians and 21.3% faculty members. More than half of them stated that they did not read any jou-rnals regularly. Mean score of knowledge, attitude and confidence to biostatistics of participants were 24.4816.32, 62.809.54 and 12.702.59, respectively. There was a significant difference between the mean score, attitude and confidence of faculty members, medical students and physicians toward biostatistics (P<0.05).
Discussion & Conclusion: The knowledge of physician and medical students was lo-wer than those of American ones. Physi-cians had the lowest level and faculty mem-ber highest level of knowledge to biostat-istics. Changing in the season of biostat-istics and epidemiology courses and traini-ng biostatistics for physician, medical stud-ents and faculty members is recommended.
M Rezaee Tavirani, M Yasemi, Mr Yasemi, M Rashidbeigi, Z Moradi, Y Aziz Pour, R Valizadeh,
Volume 22, Issue 7 (in press 2015)
Abstract
Introduction: Dyspepsia is one of the most common gastrointestinal disorders and an indication for upper gastrointestinal endo-scopy (UGIE). The aim of this study was to evaluate the prevalence of gastrointestinal disorders in patients with dyspepsia who referred to gastrointestinal clinics in Ilam during the years 2010-2011.
Materials & Methods: In this cross-sect-ional study, all documents of patients with the history of dyspepsia and epigastric pain were evaluated. Data were analyzed by SPSS, t-test, logistic regression and Chi-square tests.
Findings: A total of 1464 patients und-erwent UGI endoscopy during a one-year study (age range 1-94). 50.1% of patients were male, and gastrointestinal disorders such as hiatal hernia, reflux esophagitis, duodenal ulcer and gastric ulcer were 91.5%, 44.2%, 26.1%, 30.2%, respectively. The final diagnosis was celiac in 17patients (1%), and was gastric cancer in 6 patients (0.4%).There was a significant association between reflux esophagitis and hiatal hernia (OR=4.59).
Discussion & Conclusion: The Prevalence of dyspepsia is increasing in Ilam this could be attributed to changes in life style and dietary habits such as eating fast foods, more consumption of fat, obesity, and smoking. Finally, it is suggested that these findings can be helpful, and may offer a solution to decrease the prevalence of dyspepsia and its complications in Ilam.
Parisa Asmand, Shahram Mami, Reza Valizadeh,
Volume 23, Issue 1 (4-2015)
Abstract
Abstract
Introduction: Antisocial personality disorder has some clear symptoms such as impulsivity, unstable emotions, aggression, drinking, use of drugs, early initiation of sexual behaviors which make numerous problems in their relations with family members and those who have interaction with them and at last in society. So the aim of this research was studying the Effectiveness of Dialectical Behavior Therapy in Irrational Beliefs Treatment, Anxiety and Depression among young prisoners who have Antisocial Personality in Ilam´s male prison. Materials & Methods: This Semi-experimental project has been done by pre and post-test design. 32 subjects have been selected purposely between 18-40 years among male prisoners with antisocial personality disorder in Ilam prison. The selected people were divided randomly to two groups: control group and test group. In this study, three questionnaires have been used: the Millon Clinical Questionnaire, Johns Irrational Beliefs questionnaire , and Back Anxiety and Depression questionnaire. Findings: In this study, it was specified that this treatment has affected on the rate of anxiety (p=0.014), and irrational beliefs(p<0.05), but it hasn´t left any effect on treating depression(p=.955). Discussion & Conclusion: According to the findings obtained, it seems that Dialectical therapy is an effective way in treating some of characteristics of people with Antisocial personality disorder, due to the nature of treatment that at first focuses on person´s acceptance and credibility, and then tries to solve psychological problems.
Reza Valizadeh, Sajad Sohrabnejad, Shafiq Mehraban, Soleyman Ahmadboukani,
Volume 23, Issue 5 (11-2015)
Abstract
Introduction: The main purpose of this study was to investigate the effectiveness of cognitive-behavioral based stress management training on depression of MS female patients.
Materials & methods: this study employed a quasi-experimental research method with pre-test posttest, control group and random assignment. The statistical population consists of all female MS patients referring to Iran MS association in 2013. 24 individuals are selected by available sampling among them and were divided into intervention and control group randomly. For measuring independent variable beck’s depression inventory were used.
Findings: The results of analysis of ANCOVA showed that cognitive-behavioral based stress management training has been effective on depression reduction of MS female patients (depression: P<0/01).
Discussion & Conclusion: According to obtained results we believe that cognitive-behavioral based stress management training program has been effective on depression reduction of MS female patients. Thus this training method can be used for target groups and general population as an interventional program.
Masoumeh Shohani, Vahid Zamanzadeh, Alireza Irajpour, Leyla Valizadeh,
Volume 23, Issue 5 (11-2015)
Abstract
Introduction: Collaboration because of the effects on the function of healthcare team is considered in many countries. Complexity, ambiguity and multi-dimensional of concept have been obstacle the proper use of it. Clarity of dimensions and characteristics of the concept is the purpose of this study.
Materials & methods: In this study the concept of collaboration was analyzed based on three phases of a hybrid concept analysis, theoretical, fieldwork, and final analysis. In the theoretical phase, full texts of 273 articles in the databases were evaluated with no time limit to September 2013. 18 participants nurse were elicited in the fieldwork phase via unstructured interviews. Interviews were tape recorded and transcribed verbatim then qualitative content analysis was used to analyze fieldwork phase data. In the final step of combining the two previous stages, the overall analysis was performed.
Findings: Based on review of literature, collaboration was defined. In field work stage extracted categories based on participants experiences included 1) prerequisites of collaboration 2) actualizing of collaboration and 3) achieving a common goal. In the final stage the hybrid model was presented with integration of previous stages.
Discussion & Conclusion: The results of this study will help clarify the concept of collaboration in the healthcare system. This clarification can lead to offering comprehensive view and better understanding for use in the research and practice.
Elmira Valizadeh, Kumarss Amini,
Volume 24, Issue 2 (6-2016)
Abstract
Introduction: Some pathogenic strains of Escherichia coli can cause intestinal and external intestinal diseases. Enteropathogenic Escherichia coli is one of the most important factors of children diarrhea in developing countries. The aim of this study was to determine the prevalence of antibiotic resistance and the prevalence of tetracycline resistance genes in Escherichia coli causing diarrhea.
Materials & methods: A total of 150 stool samples of diarrheal children under 5 years from treatment centers in Tehran hospital were selected randomly, collected and finally 55 cases were confirmed as Escherichia coli with different biological and biochemical tests. Antibiogram testing was performed by disk diffusion method according to CLSI guidelines with various antibiotics. Multiplex PCR test was used for identifying the tetracycline resistance genes.
Findings: The results showed that the most resistance to antibiotics were amoxicillin and tetracycline 36.3% and 27.5%, respectively, and were reported the minimum inhibitory concentration (MIC) of the strains resistant to tetracycline, 66.6% of the strains 128 μg/ ml and 33.3 % of the strains 256 μg/ ml. The most prevalence were identified of tetracycline resistant genes, genes tetBand tetA in 6 samples (20%). TetC gene identified in 2 isolated and tetD gene in 1 isolation.
Discussion & Conclusions: Antibiotic-resistant Escherichia coli in children with diarrhea can indicate excessive use of antibiotics, the spread of antibiotic resistance gene cassettes and genetic transmission among the population. Treatment and absence of resistance gene in pathogenic strains, is necessary determine the resistance pattern and the MIC to follow up the process of resistance.
Omid Azizian Shermeh, Jafar Valizadeh, Meissam Noroozifar, Ali Qasemi,
Volume 24, Issue 5 (12-2016)
Abstract
Introduction: The use of antimicrobial compounds in plants and nanoparticles for control and treatment of disease agents have been extensively studied. The present study aimed to biosynthesis of silver nanoparticles using leaf aqueous extract of Sambucus ebulus L. and study of their antimicrobial activity.
Materials & methods: To biosynthesis of silver nanoparticles, fresh extract was prepared and added to silver nitrate solution with concentration 1 mM. Effective parameters on synthesis of silver nanoparticles such as; pH, the volume of extract, silver ion concentration, temperature and reaction time were optimized and studied to obtain individual shape and size of nanoparticles. Antimicrobial activities of extract and silver nanoparticles were studied with the Disc diffusion and MIC methods against four bacterias such as; Staphylococcus aureus (PTTC 1112), Bacillus cereus (PTTC 1154), Escherichia coli (PTTC 1399), Pseudomonas aeruginosa (PTTC 1707) and two Fungus such as; Aspergillus niger (PTTC 5012) and Candida albicans (PTTC 5027).
Findings: After adding the extract to the silver nitrate solution, the color changed to brown that represents to successful synthesis of silver nanoparticles. Silver nanoparticles showed maximum absorbance at 405 nm and they were spherical shape and the average size of them had been between 8-12 nm. These nanoparticles showed significant antimicrobial activity on samples, so that they were prevented the growth of bacterias and fungus in very low concentration.
Discussion & conclusions: Because of existing the antioxidant properties and many secondary compounds in plant, they have a role in reducing and stabilizing the nanoparticles. In this study, the silver nanoparticles synthesized by leaf aqueous extracts of S. ebulus. The silver nanoparticles showed high antimicrobial activity.
Farhad Modara, Diyana Sarokhani, Reza Valizadeh, Mandana Sarokhani,
Volume 25, Issue 2 (7-2017)
Abstract
Introduction: One of the human emotional feelings is anxiety and if this feeling becomes severe, it may lead to undesirable results. A general estimation of mean score of anxiety has not reported in Iranian society up to now. This study aims at estimating the mean score of anxiety in Iran by the systematic review and meta-analysis method.
Materials and methods: Searching was conducted using the keywords of Anxiety,Concerns,Stress,Depression and Iran in foreign databases of Pub med, Scopus, ISI, and google scholar as well as domestic ones including SID, Medlib, Magiran and Iran medex. The data were analyzed using the meta-analysis method (the random effects model). The disharmony of the studies was investigated using the I2 index. The data were analyzed by the STATA Ver.11 software.
Findings: Of 174 articles under investigation with the sample of 29839 people during years 1999 to 2016, mean score and standard deviation of anxiety was estimated to be 29.46 (Confidence interval 95%: 24.74 to 34.18). Mean score of Anxiety was estimated to be 25.96 in women, 24.00 in men, 13.13 in married people and 13.34 in singles. Mean score of apparent anxiety 45.81, hidden anxiety 45.13, stress 10.51 and depression 11.37 were estimated as well.
Discussion & conclusions: According to result of the study, mean score of anxiety is high in Iran. Furthermore, it is more in women than in men and there is not a significant difference between the married people and singles.
Rasmiyeh Asgari, Mohammad Reza Valizadeh, Korosh Jafariyan,
Volume 25, Issue 4 (11-2017)
Abstract
Introduction: Doctors undertake calculation of body fat percentage by using BIA (Bioelectrical Impedance Analysis) equipment. In this study, we measured body fat percentage without using equipment. For this purpose, an artificial neural network has been used to estimate the exact amount of fat.
Materials & methods: The sample was selected from patients admitted in a nutrition clinic in Tehran. 400 patients took part in this study. MLP neural network was used to estimate body fat percentage. The used neural network had five input neurons and ten neurons in the hidden layer. Also, cross validation method for evaluating the proposed method has been used.
Findings: The proposed method is efficient because of the results that demonstrate 2.5 units error based on cross validation. The results of experiments show that the proposed neural network for estimating body fat percentages has an average accuracy of 93%. Therefore the proposed method can accurately estimate body fat percentage of people with very high accuracy.
Discussion & conclusions: The results of this research show that the proposed method as the first method used in machine learning technique, can estimate fat percentage with high accuracy. This method can be used as a useful method without using BIA device.
Masoumeh Valizadeh Talarposhti, Ali Salehzadeh, Amir Jalali,
Volume 33, Issue 1 (3-2025)
Abstract
Introduction: Breast cancer is a significant global cause of cancer-related mortality, highlighting the urgent need for new drugs to combat this prevalent disease. This study was designed to investigate the anticancer effect of copper oxide nanoparticles conjugated with lapatinib and its effect on the expression of the caspase-8 gene in a breast cancer cell line.
Materials & Methods: Copper oxide nanoparticles were synthesized from a CuCl₂ solution, treated with D-glucose, and then linked to lapatinib. The physicochemical properties of the nanoparticles were analyzed using FT-IR, XRD, EDS, DLS, zeta potential measurement, and electron microscope imaging. The effect of the nanoparticles on the viability of breast cancer (MDA-MB-231) and normal (MRC-5) cells was evaluated using the MTT test, while the expression of the caspase-8 gene was measured via real-time PCR. Statistical differences were analyzed using one-way ANOVA in SPSS V.22, with a p-value less than 0.05 considered statistically significant.
Results: The study found that copper oxide nanoparticles conjugated with lapatinib had a spherical morphology, a surface charge of -14 mV, and a particle size of 426.3 nm in aqueous medium. These nanoparticles had concentration-dependent inhibitory effects on cancer and normal cell lines, with a 50% inhibitory concentration of 75 and 120 μg/ml, respectively, and a 3.24-fold increase in caspase-8 gene expression.
Conclusion: Copper oxide nanoparticles linked with lapatinib were more effective at stopping cancer cells than normal cells, and by boosting the levels of caspase-8, they trigger the external pathway of cell death in cancer cells.
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