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Introduction: Approximately 171 million pe-ople suffer from type 2 diabetes, worldwide. It is estimated that the figure will be 300 million people in 2025. The aim of this research was to compare executive functions of type2 dia-betic patients with normal people. Materials & Methods: This research was a de-scriptive and causal comparative study. 50 patients with type 2 diabetes were selected from Fateme-Al-Zahra diabetes centre via acc-essible sampling method. The patients, com-peleted general health, Beck depression inve-ntory and Wisconsin card sorting test questi-onnaires. Normal group consisted of 34 people from the patient’s relatives and staff of Fat-eme-Al-Zahra diabetes centre. For analyzing the data covariance test was used. Findings: The results showed that after deter-mining depression as the Covariate variable, type 2 diabetic patients had lower executive functions than normal people. These patients had more perseveration errors than normal people. Discussion & Conclusion: Executive functions (cognitive flexibility and abstract ability) have deficiency among diabetic patients and this deficiency is influenced by depression. Instr-ucting cognitive flexibility to these patients can decrease their deficiencies in executive fu-nctions.

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Introduction: Chalcones and their derivatives have strong anti-cancer activity. The aim of present study was to evaluate the cytotoxicity effect of new synthetic chalcone on Hela cell line.
 Material &methods: Hela cell line were cultured in RPMI1640 liquid medium along with with 10% inactivated fetal bovine serum (FBS) and antibiotics. Cells were cultured with various concentrations of chalcone for 72 hours and were analyzed by using the MTT test. Statistical analysis was performed by using of students T-Test. Apoptosis were examined on Hela cell lines after 24 hours in concentration of 40 µg/ml chalcone by Microscopic method.
 Findings: The results of this study showed that new synthetic chalcone at concentrations of (10, 20, 40, 60, 80, 160 µg/ml) inhibit the growth of Hela cell line 63.75 ،56.58،54.46،33.60،18.74،14.96 after 72 hours, respectively. The highest percentage of growth inhibition at a concentration of 10 µg/ml was 63.753. The IC50 value for Hela cells was 40 μg/ml. Our findings showed that grow the cells have reduced at concentrations of 10 and 20 µg/ml significantly compared to control group after 72 hours.
 Discussion & Conclusion: Based on our research, synthetic chalcone has anti proliferation activity against HeLa cells lines. This activity is related to its effect on cell cycle by inducing G2 / M phase. Further studies are needed to demonstrate the molecular mechanisms of this new chalcone