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Showing 15 results for Sami
Amir Ziaee, Sima Hashemipour, Samiramis Ghavam, Amir Javadi, Ramak Ghavam, Ameneh Barikani, Neda Esmailzadehha,
Volume 21, Issue 2 (6-2013)
Abstract
Background: Heart disease, particularly coronary heart disease is a major cause of mortality among patients with diabetes mellitus. High level of hs-CRP is considered as a risk factor for heart diseases. Treatment with pioglitazone in patients with or without type II diabetes decreases serum concentrations of hs-CRP. The purpose of this study was to compare the effects of pioglitazone and metformin on hs-CRP level.
Material and methods: A randomized clinical trial was performed on 40 patients with type 2 diabetes and defined inclusion criteria. Patients were divided into two groups receiving metformin and pioglitazone. Blood levels of cholesterol, triglycerides, fasting blood glucose, Alanine transaminase, Aspartat aminotransferase, HbA1C and hs-CRP were measured in all subjects before and after 3 month drug therapy. The average change in each group before and after drug therapy were analyzed by paired T-test, the mean change between groups were compared by T-test.
Results: In both groups, hs-CRP level was significantly decreased after drug therapy. The mean change of hs-CRP, HbA1C, cholesterol was significantly higher in metformin treated group.
Conclusion: Since the average reduction in the level of hs-CRP, cholesterol and HbA1C in diabetic patients treated with metformin is significantly higher than patients treated with pioglitazone treatment with metformin is recommended to reduce risk of heart disease
S Sami, N Karimiani, S Saeid Ebrahimi, M Hakimi,
Volume 21, Issue 4 (10-2013)
Abstract
The purpose of this study was to survey motor proficiency in children with ADHD. This study was descriptive, comparative and non-intervention. Forty children selected by regarding to aims of study and, assigned into two groups (ADHD and control) randomly. Bruininks-oseretsky test of motor proficiency and Conner's Parent and teacher Questionnaire was used for data collection. The parents or the teachers of all children completed questionnaires. The symptoms of ADHD were conduct disorder, oppositional defiant disorder, anxiety, mood, and other internalizing disorders. A standardized algorithm was applied to the PACS to derive each of the all DSM-IV ADHD symptoms, providing operational definitions for each behavioral symptom. These were combined with items that were scored zero (‘‘never’’) to 3 (‘‘extreme’’) in the teacher-rated Conners’ ADHD subscales, to generate the total number of hyperactive-impulsive and inattentive symptoms of the DSM-IV symptom list. The t –student test were used to determine the statistical difference in variables of study in significant level of p≤0/05. All data was analyzed using the SPSS. The results indicated that Gross motor skills, Fine motor skills and motor proficiency in normal children better than children with ADHD do.
A Haseli, M Ghiasian, F Seififard, M Ebrahimzadeh, K Basami,
Volume 22, Issue 7 (in press 2015)
Abstract
IIntroduction: Maternal Mortality Rate ind-ex is a reflection of public health status in society. Mothers are the main family axes, so maternal mortality and disability will affect all dimensions of family health, so this study was performed aimed to inv-estigate the frequency and effective factors on pregnant women´s mortality in Ilam Province, Iran, 2002-2010.
Materials & Methods: This cross-sectional, short-term study was performed using data from the clinical records and completed questionnaire for pregnant women´s deaths in Ilam province. The data was analyzed using descriptive and analytical statistics and chi-square by SPSS software version 7.
Findings: results showed that the frequency of maternal mortality in the study was 22 cases, and Maternal Mortality Rate was 25.51 per 100,000 live births. The highest
(22.73%), in the age group 30 to 35 years (36.36%), first pregnancy (31.9%), urban
number of maternal deaths were in 2004 resident (59.09%), illiterate or poorly educated (50%), housewife (90.9%), receiving special care during pregnancy (81.8%), Cesarean delivery (54.54%) and wanted pregnancy (72.7%). Bleeding was the most common cause of maternal mor-tality (22.7%). The cause of maternal mo-rtality has statistically significant associ-ation with maternal education level (P=0.
031), maternal age (P=0.029), requiring to special care(P=0.003), the time of dea-th(P=0.019)and the type of delive-ry(P=0.019).
Discussion & Conclusion: According to rel-ative stability and lack of a clear trend in the maternal mortality ratio a basic action should be done by administrators and pol-icy makers in surveillance system of mate-rnal mortality and morbidity in designing and developing this program
Bakhtiyar Tartibiyan, Fakhradin Yagobnezhad, Sirvan Mohamad Amini, Sadeg Maleki, Naseh Abdollahzade, Samih Faridniya,
Volume 24, Issue 2 (6-2016)
Abstract
Introduction: Cardiovascular disease prevention in pediatrics is important. The aim of this research was to investigate the relationships and response of incremental exercise on inflammatory, immune and hormonal markers in pediatrics.
Materials & methods: Thirty healthy non-active pediatrics boys with the age range of 9-11 years old participated voluntarily in this study, and were randomly divided into control (C; n=11) and exercise group (E; n =11). Blood and salivary samples were collected in the two stages: prior to GXT (Graded exercise test) exercise test and immediately after graded exercise test. ELISA method was used for measurement of salivary immunoglobulin A, C-reaction protein, cortisol and fibrinogen serum levels. The research data were analyzed using the Pearson correlation coefficient, Multiple Linear Regression, independent and paired t test.
Findings: CRP (p=0.043), fibrinogen (p=0.039) cortisol serum (p=0.001) and S-IgA (p=0.021), concentrations were significant increased immediately after the exercise in the exercise group. A significant relationship was observed between CRP and fibrinogen (r=0. 525, p=0. 048), CRP and S-IgA (r=0. 621, p=0. 022), CRP and cortisol serum (r=0. 712, p=0. 012), fibrinogen and S-IgA (r=0. 638, p=0. 028), cortisol and fibrinogen serum (r=0. 562, p=0. 038), also cortisol and S-IgA (r=0. 734, p=0. 003) in the exercise group.
Discussion & Conclusions: Incremental exercise not only significantly increases inflammatory immune-saliva and stress hormonal markers in non-active pediatrics, but also cardiovascular risk factors in this paediatrics. Rather reveals the close relationships between these indicators that can be effective in predicting cardiovascular risk factors in paediatrics.
Mrs Narjes Rahmati, Mr Mohamad Ali Asghari Moghadam, Mr Mohamadreza Shairi, Mr Mohsen Paknejad, Mrs Zahra Rahmati, Mrs Maryam Ghassami, Mr Nader Marofi, Mr Hosein Naeb Aghaei,
Volume 25, Issue 1 (5-2017)
Abstract
Introduction: Catastrophizing about pain has been identified as one of the most important psychological variables in transition of acute pain to chronic disabling pain. This study aimed at investigating the psychometric properties of a Persian-language version of the pain catastrophizing scale (PCS) amongst a sample of patients with chronic pain.
Materials & methods: This cross-sectional study was conducted on 195 patients with chronic pain using convenience method. Participants completed a group of self-report measures including the Persian versions of PCS, pain severity, daily pain-related interference, physical disability, depression, anxiety, catastrophising, positive and negative effects and pain self-efficacy beliefs. Data were analyzed by Pearson correlation and exploratory and confirmatory factor analysis methods.
Findings: The factor structure of the PCS was examined, using exploratory and confirmatory factor analysis. The results indicated that PCS is conceptualized within a two-factor model, namely magnification and rumination/helplessness. Results also indicated that the PCS and its two subscales have good internal consistency (alphas range from 0.80 to 0.89) and test-retest reliability (rs range from 0.71 to 0.81 (with a 7-14 days interval)). The results of correlation analysis among PCS and its two subscales with measures of pain, interference, disability, depression, anxiety, catastrophising, positive and negative effects and pain self-efficacy beliefs support both the convergent and divergent validity for the PCS and the two subscales of magnification and rumination/helplessness.
Discussion & conclusions: To sum up, the Persian version of the PCS has satisfactory psychometric properties and can be administered amongst the Iranian population with chronic persistent pain.
Rahmatolah Mohamadipoor, Shahrokh Fouladvand, Farshad Sabzali, Samireh Ghale Dare,
Volume 25, Issue 5 (1-2018)
Abstract
Introduction: providing health care is one of the basic needs of every community for which major part of the Government's financial resources is allocated. Inadequate resources allocated to treatment part have created a significant gap between the available resources and needed resources. This issue has made it a necessity to create resources through the use of proprietary revenues. In this context, the present study sought to identify factors affecting the uptake of dedicated revenues in Ilam University of medical sciences.
Materials & methods: the present research in terms of its objectives is functional in nature, and in terms of the method is descriptive and analytical. Research population is all the hospitals under the supervision of Medical University of Ilam and also its headquarters in 2014. For the sampling, relative stratified sampling methods and for data collection a researcher-made questionnaire is used. To evaluate the reliability, the coefficient of Cronbach’s alpha was used which was 0.93. The data was analyzed using SPSS software version 19.
Findings: the results suggest that the use of HIS as an advanced software, specialist staff, and detailed and accurate recording of therapeutic measures conducted in the hospital bills on the receipt of dedicated revenues has a significant impact on revenues while improving the processes and procedures for collection of receivables and remove the manual system of the receipt income (the Fund) not has not a significant impact on revenues.
Discussion & conclusions: according to the findings of this research, Ilam University of medical sciences can increase its revenues by using HIS as advanced software and also by specialist staff for the detailed and accurate recording of therapeutic measures conducted in the hospital bills.
Miss. Mahin Kokhazadeh, Mr. Hossein Rajabi, Ms. Samira Rasaneh, Mr. Mohammad Ali Askari, Miss. Parisa Taheri,
Volume 25, Issue 6 (3-2018)
Abstract
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Introduction: One of the most common applications of medical isotopes is in treatment of cancer and hyperthyroidism using Iodine-131. The Iodine-131 cumulates in cancerous cells and acts as a source of radioactive emissions. Apparently, local and temporal distributions of the radioactive material are different in various organs. In this paper, the effect of radioactive Iodine distribution on the amount of exposure at different distances has been investigated.
Materials & Methods: This analysis has been carried out using adult NCAT phantoms, Monte-Carlo simulation, and GATE code. By applying the same amount of activity on five different organs of the phantom, the quality and quantity of energy has been computed as well as the amount of emitted exposures at distances of one, two, and three meters. Then, by setting thyroid as the basis, the difference of exposure emitted from other four organs has been calculated and analyzed using KS test.
Findings: Simulation results had been showed that the amounts of exposure that emitted from aforementioned organs are significantly different at the distance of one meter whereas this difference diminishes significantly at distances of two and three meters. In other words, the effect of radioactive Iodine integration location on the emitted exposure is being trivial as the distance increases.
Discussion & Conclusions: Distinct TEDE values must be defined for each of the aforementioned organs and confirmed before releasing patients who will be faced to the others at short distances. Otherwise, guidelines must be considered for the others who will be faced to the released patient.
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Elnaz Panahi, Ali Reza Mousavi, Masoud Sami, Maryam Mirlohi,
Volume 27, Issue 2 (6-2019)
Abstract
Introduction: This study aimed to compare the storage stability of tomato paste packaging of cans and a container with the brand name of "Robby" during 6 weeks.
Materials & Methods: Four cans of tomato paste were prepared from brand A. Sample 1 was covered with the plastic lid after opening. Sample 2 was transferred into a container with the brand name of "Robby". Tomato paste of cans 3 and 4 were contaminated with Aspergillus flavus spore ssuspension (t 2×106spore/ml) and homogenized in a sterile container. Subsequently, an equal amount of contaminated tomato paste was transferred into the original can (sample 3) and the "Robby" container (sample 4). Samples were stored in a refrigerator at 4°C for 6 weeks. Samples 1 and sample 2 were evaluated regarding acidity, Brix, pH, vitamin C, as well as total bacteria, mold, and yeast count. However, samples 3 and 4 only were analyzed in terms of total bacteria, mold, and yeast count with two replications. All the experiments were individually repeated on another tomato paste with a different brand name. Ethics code: 395833
Findings: After the second week, there was a 62% decrease and a 4% increase in vitamin C and Brix levels in the tomato paste in the can. However, the reduction in vitamin C level (5%) and the Brix changes were not significant in the "Robby" container. The gradual increase of acidity was observed in both treatments. Nevertheless, there was an increase in the acidity of the tomato paste kept in the can (28%) and "Robby" container (22%) at the end of the sixth week (P<0.05). The "Robby" container had no significant effect on pH and microbial groups (P> 0.05).
Discussion & Conclusions: The "Robby" container definitely provides better conditions for preserving the chemical properties of tomato paste than common means of tomato paste storage.
Khusro Shirini, Fariba Nazarpour, Samira Soleimani, Mehrdad Kazemi, Meghdad Kazemi, Vahid Hatami, Mahshid Taab,
Volume 28, Issue 2 (5-2020)
Abstract
Introduction: Any kind of behavior or practice that conflicts with the values and norms accepted by the community is known as social harm, which can disrupt the function of the individual, the family, and the community. This study aimed to investigate the factors leading to social injuries among dormitory students.
Materials & Methods: This descriptive-analytic study was carried out on 337 dormitory students of the state universities in Ilam during 2016. The data were collected using a researcher-made questionnaire with 69 items. Face validity, relative content validity coefficient (CVR), and content validity index (CVI) were used to evaluate the validity of the instrument. In this study, the CVI and CVR were obtained at 0.85 and 0.76, respectively. The reliability of the questionnaire was assessed by Cronbach's alpha coefficient at 0.87. Data were analyzed in SPSS software (version 20) through descriptive statistics to describe the data. Moreover, inferential statistics were used to analyze the data.
Findings: The Chi-square test results showed a significant difference between gender and the damage induced by the illegitimate relationship (P<0.05). Moreover, social injuries correlated significantly with friend status, being isolated, lack of familiarity with life skills, and lack of academic and educational facilities in dormitories (P<0.05).
Discussion & Conclusions: In this study, family problems, history of depression, presence of peer group and friends, and being far away from family were the most important factors affecting social harm in students. Therefore, it is suggested to develop appropriate strategies to prevent the emergence of social harms.
Mohammad Amin Edalatmanesh, Samireh Nemati, Habibollah Khodabandeh,
Volume 29, Issue 5 (12-2021)
Abstract
Introduction: Stem cell-based therapies create new hope for the treatment of Alzheimer's disease (AD). Since the mesenchymal stem cells have neuroprotective and regeneration effects, this study aimed to investigate the memory, learning, and antioxidant capacity of the hippocampus following human adipose-derived mesenchymal stem cell (Ad-MSC) transplantation in Trimethyltin (TMT) rat's model of AD.
Material & Methods: In total, 24 male Wistar rats were randomly divided into three groups (8 animals per group) of control (without any treatment), TMT+PBS (Trimethyltin+Phosphate buffer saline), and TMT+Ad-MSC (Trimethyltin+Stem cells). For the induction of the AD, TMT was peritoneally injected (8 mg/Kg). After 48 h, the TMT+Ad-MSC group received 1 million stem cells intravenously. One month after transplantation, avoidance and working memories were evaluated. Afterward, hippocampal levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and malondialdehyde (MDA) were measured using ELISA.
Findings: The results showed a significant increase in the percentage of correct motor frequency in the Y maze, a decrease in the spent time in the dark room (P<0.05), and an increase in the latency time to the dark room in the TMT+Ad-MSC group, compared to the TMT+PBS group (P<0.01). Moreover, a significant increase in the CAT, SOD, and GPX enzymes activity, as well as a decrease in the MDA level in the hippocampus were observed in the TMT+Ad-MSC group, compared to the TMT+PBS group (P<0.05).
Discussion & Conclusion: Xenotransplantation of human adipose tissue stem cell improved learning and memory, reduced tissue oxidative stress, and increased hippocampal antioxidant capacity in an animal model of AD.
Khadijeh Abdal, Samira Mostafazede, Nastaran Ghorbani, Mohammadreza Hafeziahmadi,
Volume 30, Issue 5 (12-2022)
Abstract
Introduction: The role of E-cadherin and CD44 has been proven in the development and progression of cancerous and precancerous lesions. It seems that these two markers have a high ability to evaluate the premalignancy of lichen planus lesions and oral leukoplakia. This study aimed to investigate and compare the expression of CD44 and E-cadherin markers in oral leukoplakia, lichen planus, and oral squamous cell carcinoma (SCC).
Material & Methods: This analytical-descriptive study was conducted on 60 blocks of lichen planus, leukoplakia, and squamous cell carcinoma. The blocks were stained by CD44 and E-cadherin antibodies. The obtained data were analyzed in SPSS software (version 22), and a P-value of 0.05 was considered statistically significant.
Findings: Only 30% of the SCC samples expressed the CD44 marker, while 40% and 50% of leukoplakia and lichen planus samples expressed the CD44 marker, respectively. The expression of the E-cadherin marker in SCC samples was 40% in the range of staining, while it was 50% and 60% in leukoplakia and lichen planus, respectively. There was not a significant difference between the staining intensity of CD44 and E-cadherin (P<0.16). However, in SCC, 70% of the cases showed mild to moderate expression intensity that was statistically significant, compared to lichen planus and leukoplakia (P<0.004).
Discussion & Conclusion: It seems that the severity of CD44 and E-cadherin incidence can indicate the changes in dysplasia and premalignancy of oral lichen planus and leukoplakia, compared to oral carcinomas.
Zohreh Mahdian, Samira Vakili, Saeed Rezayi, Masoud Gholam Ali Lavasani,
Volume 31, Issue 2 (6-2023)
Abstract
Introduction: Neurodevelopmental disorders are group of neuropsychiatric disorders that occur in childhood and cause disruption in the growth and development of the brain or central nervous system in children. According to research results, children with neurodevelopmental disorders are weak in physical, cognitive, emotional, and social skills. This study aimed to develop a multimedia educational program with a neuropsychological approach and evaluate its effectiveness in the social skills of children with neurodevelopmental disorders.
Material & Methods: In this study, initially, a multimedia educational program with neuropsychological approach was designed, and the content validity of the tool was confirmed by experts. The statistical population of this study included male students aged 7-11 years old with neurodevelopmental disorder in Tehran, Iran. Using the purposefully convenience sampling method, and after administering Stanford-Binet Test of Intelligence (Fifth Edition), 100 children with neurodevelopmental disorder and natural IQ level and above were selected and randomly assigned into experimental and control groups. The experimental group was subjected to 90-min 24 multimedia educational sessions with neuropsychological approach. On the other hand, the control group received no intervention. They were then followed-up after one month and a half. The required data were collected using Social Skills Rating System (Gresham and Elliot, 1999) as pre-test, post-test, and the follow-up.
Findings: The results of repeated measurement MANCOVA showed the effectiveness of the multimedia educational program with neuropsychological approach in the improvement of social skills of children with neurodevelopmental disorder (P˂0.01; Effect Size 0.35). Furthermore, it was shown that the effect of this program with neuropsychological approach on the social skills of children with neurodevelopmental disorder was constant even after one month and a half.
Discussion & Conclusion: A multimedia educational program with neuropsychological approach can be used to increase and strengthen the social skills of children with neurodevelopmental disorders.
Mahdi Amini, Mohammad Abdolahpur, Mozhgan Lotfi, Samira Masoumian,
Volume 31, Issue 2 (6-2023)
Abstract
Introduction: The personality inventory for ICD-11 (PiCD-11) was developed in line with the introduction of the International Classification of Diseases (ICD-11). This study aimed to investigate adaptation, validity, reliability, and factor structure of the PiCD-11 in an Iranian sample.
Material & Methods: Participants in this study were (67.6% female, 32.8% clinical sample) 417 students from state universities in Tehran. They were requested to complete the paper-based forms of the Personality Inventory for ICD-11 (PiCD-11), the Short form of Personality inventory fo DSM-5 (PID- 5-BF), as well as the Big Five Inventory (very brief for, BFI-10).
Findings: Cronbach's alpha coefficient for five factors of the PiCD ranged from 0.73 (dissocial) to 0.82 (negative affectivity). The inventory domains also had a significant correlation (P=0.001) with PID-5-BF and BFI-10 scales. Exploratory and confirmatory factor analysis also confirmed the five-factor structure and optimal fit of the model related to the PiCD.
Discussion & Conclusion: The 60-item inventory based on the International Classification of Diseases (PiCD-11) has good reliability and validity, and can be used for various clinical and research purposes in Iran for the Persian speaking population.
Noosheen Samimi, Abbas Doosti, Abbas Mirzaei,
Volume 31, Issue 3 (8-2023)
Abstract
Introduction: Cancer is a complex disease in which gene expression changes. This study was conducted with the aim of investigating the effects of MT1JP lncRNA in controlling lung cancer cells.
Material & Methods: TC-1 [JHU-1] cells were transfected with pcDNA3.1(+)-MT1JP, Plko.1-EGFP-PURO-siRNA and empty plasmids, and the expression of MT1JP gene and siRNA fragment was confirmed by RT-PCR reaction. The role of MT1JP in migration was investigated by scratch assay and apoptosis by flow cytometry. The expression change of candidate genes involved in apoptosis and cell proliferation (Bim, AKT, Bax and Bcl-2) was evaluated by q-PCR reaction.
Findings: The results showed that the expression of Bim gene showed a significant increase in the presence of high expression of MT1JP, while the expression of Bim gene decreased significantly with silencing of MT1JP by siRNA. The expression of Bax and Bcl-2 genes showed a significant increase and decrease, respectively, in the presence of high expression of MT1JP. In the cells transfected with pcDNA3.1(+)-MT1JP, the AKT gene showed a decrease in expression, and on the other hand, in the cells transfected with siRNA, the AKT gene had a significant increase in expression (p < 0.05). Also, the scratch assay results showed that MT1JP lncRNA has an inhibitory role on cell migration. Flow cytometry data showed that transfection by pCDNA3.1(+)-MT1JP could increase cell apoptosis levels.
Discussion & Conclusion: The present study showed that lncRNA MT1JP inhibits cell proliferation and migration and at the same time increases apoptosis of TC-1 [JHU-1] cells. This study may help improve our understanding of lung cancer, however further studies are needed.
Zohreh Mahdian, Samira Vakili, Saeed Rezayi, Masoud Gholam Ali Lavasani,
Volume 31, Issue 5 (12-2023)
Abstract
Introduction: Neurodevelopmental disorders begin in childhood and lead to a weakening of physical, cognitive, emotional and social skills in affected children. The aim of this study is to develop a multimedia educational program and to evaluate its effectiveness on problem solving in children with neurodevelopmental disorders.
Material & Methods: In this study, a multimedia training program with a neuropsychological approach was first developed and the content validity of the tool was confirmed by experts. The effectiveness of the program was then evaluated in a quasi-experimental study with a pre-test, a post-tesand a follow-up phase. The participants in this study were children with neurodevelopmental disorders whose male students were studying in Tehran in the academic year of 1400-1401. The children were examined using the Tehran Stanford-Binet Intelligence Test, and 100 children with neurodevelopmental disorders were selected based on the available sampling method and randomly divided into two groups, the experimental group and the control group. The experimental group completed 24 -training sessions that focused on a multimedia training program with a neuropsychological approach. Each session took place five times a week and lasted 90 minutes. The instrument used in this research were London Tower Test (Shalis,1982) , which was used as a pre-test, post-testand for the follow-up studies. The data were then analyzed using repeated measurement tests and multivariate analysis of variance (MANCOVA).
Findings: The results showed that the multimedia training program can influence the problem-solving skills (p≤0/01) of children with neurodevelopmental disorders. It also showed that the effect of this instruction was constant even after 1/5 months.
Conclusion: multimedia training program with Neuropsychological approach enhance problem solving of Children with neurodevelopmental disorders.
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