Introduction: Increasing drug resistance against different antibiotics in most bacteria the cause is increased interest in the development of natural antimicrobial compound. The aim of this study was to evaluate the antibacterial effect of ethanol extracts of Ferula assafoetida, Carum copticum and Mentha piperita strains on standard ‌pathogenic bacteria.

Materials & methods: Plant extract was performed by maceration method. Well diffusion, disk diffusion and microdilution method was used to determining the minimum inhibitory concentration (MIC) each of the extracts against four species of bacteria, including methicillin-susceptible and methicillin-resistant Staphylococcus aureus, Escherichia coli O157: H7 and salmonella typhimurium.

Finding: The minimum inhibitory concentrations of Ferula assa foetida, Carum copticum and Mentha piperita extract for methicillin-resistant Staphylococcus aureus was 50, 25, 3.25 mg/ml respectively and for methicillin- susceptible Staphylococcus aureus was 25, 25, 3.25 mg/ml. The minimum inhibitory concentration of Carum copticum and peppermint on E.coli O157:H7 was 50, 25 mg/ml while ferula assa foetida had no effect. The minimum inhibitory concentration of Mentha piperita  on Salmonella typhimurium was 12.5 mg/ml.

Discussion & Conclusions: Therefore, according to the results, natural compounds such as essential oils and plant extracts recommended to Control disease.