|
|
|
 |
Search published articles |
 |
|
Showing 2 results for Fatahi rad
D Amini, F Keshavarzi, A Fatahi Rad,
Volume 22, Issue 4 (9-2014)
Abstract
Abstract
Introduction: Staphylococcus aureus is one of the important agents of many infections in hospitals and society. Increasing Staphylococcus aureus resistance to antibacterial drugs is one of the major health concerns, therefore studying antibiotic resistance of Staphylococcus aureus is very important and it has a main role in preventing creation of resistant strains.
Materials and Methods: The antibiotic resistance of 150 Staphylococcus aureus isolates from various clinical specimens was determined by disk agar diffusion (DAD) and polymerase chain reaction (PCR) methods. Statistical analysis of data has performed by SPSS and Microsoft Office Excel software.
Findings: Using the DAD method, 77/33% (116/150) of the Staphylococcus aureus isolates were resistant to Methicillin and 47/33% (71/150) were resistant to oxacillin. The results indicated that primer MR3,4 was more appropriate than primer MR1,2 for the detection of mecA gene in MRSA.
Discussion and Conclusion: The results of this study can provide guidance for physicians toward a more appropriate treatment of Staphylococcus aureus infections in Iran, thereby preventing the emergence of further antibiotic resistance among Staphylococcus aureus. Our results also revealed the need for further investigations using a higher number of specimens representing a wider variety of locations to determine the antibiotic resistance patterns in our state more precisely.
M Radpour, P Ashtari, A Fatahi Rad, B Alirezapour, F Keshavarzi@gmail.com,
Volume 22, Issue 6 (1-2015)
Abstract
Introduction: Silicate nanoparticles are highly important in medical and treatment field due to their biocompatibility as well as ease of preparation and surface modif-ication. Through using various surface co-atings of nanoparticles, optimal and stable biomedical properties can be created for these nanoparticles. Therefore, this study aimed to evaluate the in vivo and in vitro login of these nanoparticles.
Materials & Methods: In this study, Iodine-131 radiopharmaceutical stabilized by using silver on magnetite (Fe3O4) was used while synthesizing silicate magnetic nanoparticles including and it was stabilized in silicate nanoparticles. Then, entry of nanoparticles in MCF-7 breast cancer cell line and mouse was studied. Synthesis is done using sol-gel in the reverse microemulsion with Tetra-etoxy Silane reactive (TEOS) as the mon-omer, 3-amino propyl tre-autoxy silane (APTS) as monomer and the control agent of functional groups and zeta potential of nanoparticles.
Findings: TEM results showed that the av-erage size of the nanoparticles was about 40 nm and about 80 percent of the primary iodine-131 was encapsulated in the nanop-articles. Also, the stability of nanoparticles was more than 99 percent in the carrier solution. Moreover, the highest entrance efficiency was 53-54% 2 to 4 hours after the beginning of cultivation.
Discussion & Conclusion: The prepared Silicate magnetic nanoparticles in this study can be used for simultaneous diagnosis and treatment of diseases.
|
|
