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Showing 2 results for Beigi boroujeni

Mandana Beigi Boroujeni, Nasim Beigi Boroujeni, Masoud Beigi Boroujeni, Soodabeh Zare, Afsaneh Shafiei,
Volume 23, Issue 4 (10-2015)
Abstract

Introduction: Low dose treatment with aspirin could result in endometrial improvement, decrease of abortion and consequently, an increase in uterine receptivity. Although many studies have been conducted on the effect of low dose of aspirin on the endometrium, there has not been any report on the effect of prescribing low dose of aspirin on the vascular density of endometrium. Thus, it was essential to conduct a study on this subject.
 Materials & methods: 15 female NMRI mice were used in this study. They were divided into three groups: control, sham and experimental groups. At first, in all groups, pseudo-pregnancy was induced and then the sham group received an injection of sterile water. The experimental group received low-dose of aspirin (7/5mg/kg) twice a day. Ovarian hormone levels were measured after 4.5 days of pseudo-pregnancy. Then the animals were sacrificed and the uterine horns were sampled for measurement of vascular density at implantation period. Finally, our results were statistically analyzed.
 Findings: Vascular density in the endometrium between two groups (control-experimental and sham-experimental) showed a statistically significant difference (P≤0/05).
 Discussion & Conclusion: Low-dose of aspirin seems to lead in changes of vascular density in the endometrium that may be effective on the embryo implantation.


Nasim Beigi Boroujeni, Maryam Hormozi,
Volume 32, Issue 3 (8-2024)
Abstract

Introduction:  Oxidative stress is involved in the pathophysiology of neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and multiple sclerosis. It seems that the intake of exogenous antioxidants may be effective in preventing, treating, and reducing the complications of these diseases. Astaxanthin is a carotenoid pigment with antioxidant and anti-inflammatory properties, protecting the nervous system. The present study aimed to assess the effect of astaxanthin on the amount of malondialdehyde and the activity of antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase) after oxidative stress with hydrogen peroxide in the human neuroblastoma cell line BE (2)-C.
Material & Methods: Human neuroblastoma cells were treated in this study with different concentrations of astaxanthin (25, 50, and 100 μM) or 50 μM ascorbic acid (positive control) for 24 h. To induce oxidative stress, they were exposed to hydrogen peroxide at a concentration of 400 μM for 2 h. There was also a control group without treatment and without inducing oxidative stress. The amount of malondialdehyde as an index of oxidative stress and the activity of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase were measured using calorimetric methods.
Results: The obtained results demonstrated that the malondialdehyde concentration was significantly reduced in the groups treated with different concentrations of astaxanthin and ascorbic acid compared to the hydrogen peroxide group (P<0.05). The activities of superoxide dismutase, catalase, and glutathione peroxidase also increased significantly in these groups compared to the group with oxygenated water (P<0.05).
Discussion & Conclusion: Astaxanthin appears to counteract the oxidative stress caused by hydrogen peroxide by lowering malondialdehyde levels and increasing the activity of antioxidant enzymes in BE (2) C cells, thereby protecting the cells from the impact of oxidative stress


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مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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