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Introduction: Imipramine is a widely prescribed tricyclic antidepressant. However, the routine control of this drug in assay and content uniformity requires a highly sensitive and precise analytical attitude. The aim of this research was to perform assay and content uniformity in tablet samples by high performance liquid chromatography with fluorescence detection. Materials and Methods: As, nowadays, prescription of imipramine tablets is increasing, it seems necessary to improve their quality control. So, 10 and 50 mg tablets of imipramine were randomly collected from market retailers. The chemical structure and inherent fluorescence of imipramine were a good motivation for performing assay and content uniformity in tablet samples by developing and validation of high performance liquid chromatography and fluorescence detection. These experiments were compared with imipramine standards. Findings: The results showed that imipramine could be determined by high performance liquid chromatography with fluorescence detection within 2 minutes. The detection limits(signal-to-noise ratio=3) for the examined antidepressant was 0.2ng/ml. Assay and content uniformity of the tested products met the requirements stated in accredited pharmacopoeias. Based on the statistical t-test, there is no significant difference between the test and reference products. (p>0.05) Discussion & Conclusion: The results of this study demonstrated that the developed and validated HPLC method with sensitive florescence detection can be used in assay and content uniformity of imipramine. From intra- and inter-day coefficient of variations, it can be concluded that this method have a high accuracy and precision. Very low detection limit, wide dynamic range, appropriate accuracy and precision, ability in separation on a polymeric based PRP column in a short time with sufficient robustness are, certainly, the positive aspects of the developed and validated method.

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Introduction: Chronic low back pain is one of the most important and common indust-rial societies’ problems and the significant cause of disability. The purpose of this study was to investigate the effect of yoga exercises on spinal flexibility, pain and functional disability in women with chronic lumbar disk herniation. Materials & Methods: This double-blind randomized controlled trial was performed in Zahedanin 2010. Twenty-eight patients with chronic lumbar disk herniation were randomly assigned to either a Yoga (n=14) or a general exercises group (n=14). Before and after intervention, we assessed pain through Visual Analogue Scale (VAS), Depression with Beck Depression Invent-ory II (BDI-II), lumbar lordosis with flexi-ble ruler, range of lumbar flexion using Modified Schober test, and disability with The Oswestry Disability Index (ODI). The treatment program was 16 sessions of exer-cise which lasted 8 weeks and was perfor-med twice per week.Data were analyzed using paired and independent t-test in SPSS Version 17 software. Findings: The mean pain was decreased from 6.7±1.1 to 3.4±1.4 in the yoga group and from 6.5±0.9 to 3.7±0.9 in the general group (P<0.0001). The mean disability, depression andlordosis were decreased and range of lumbar flexion was increased in both groups (P<0.0001). There was no sign-ificant difference between two groups rega-rding to all study variables (P>0.05). Discussion & Conclusion: The results showed that both yoga and general exerc-ises decreases pain, disability, depression and angle of lumbar lordosis and increases range of lumbar flexion in women with chronic lumbar disk herniation.

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Introduction: Pain is the most common problems in the post cesarean period. Today, despite technological development in health care setting the usual method of pain relief after surgery is inadequate. Materials & Methods: This study was a blind clinical trial which performed in Mustafa Hospital, Ilam, Iran. 80 pregnant women who referred to delivery ward for elective cesarean and they had inclusion criteria for study were selected with convenience sampling and were randomly assigned to two groups. The visual analog scale was used to determine the pain intensity. To relief pain in the intervention group, each of foot and hands were massaged for 5 minute. If pain is not controlled and based on the request of patient, we used the routine analgesic to relief pain. In the control group if the patient requested to relief the pain, only routine analgesic were used. Then the intensity of pain before and immediately 90 minutes after intervention was evaluated. Also, the analgesic consumption, initiation of breast feeding and patient's satisfaction were measured. Findings: The finding of the study showed that, there was no significant differences between two groups in pain intensity before massage (P>0.05). However, immediately and 90 minutes after intervention there were significant differences between two groups in pain intensity, need to analgesic, starting of breastfeeding and patient's satisfaction(P<0.001).This differences indicates reduced pain intensity in the intervention group. Discussion & Conclusion: According to the finding, hand and foot massage are associated with the reduction of pain inten-sity and it can be used as a complementary method to reduce pain and increase the patient's satisfaction.

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Introduction: Cervical cancer is the second fatal cancer among women in developing countries and seventh in developed count-ries. Screening cervical cancer to find genes and proteins that play a role in the develop-pment of diagnostic and therapeutic biom-arker, in the other hand, molecular mech-anism of tumor genesis is also associated to the protein cluster that will change in dis-ease, so discovery of protein clusters appear to be necessary. In this study, for better resolution proteome of cervical cancer tissues is analyzed by proteomic techn-iques. Materials & Methods: Proteins extracted from the normal and cervical cancer tissues, then protein separated in first (IEF) depe-nding on their isoelectric pH on strip. Second dimensional SDS page elect-rophoresis to separate proteins by molecular weight was performed. For detecting prot-ein spots, both gels were silver stained. Finally for bioinformatics and statistical analysis (clustering analysis and principal component analysis) of proteins in the two groups was studied with the progenesis same spot software. Findings: Bioinformatics and statistical analysis of two-dimensional gel electroph-oresis techniques obtained 158 protein spots from both excremental groups. 19 protein spots were more expression in cancer than normal groups whereas 18 pro-teins in normal have more expression than cancer groups. Clustering analysis divided proteins into two main clusters that indi-cated there is an expressed protein is similar in each cluster which these proteins can provide similar performance in terms of testing or indicating its presence in the same biological pathway. PCA analysis confirmed the results of clustering and showed the protein has been classified in accordance with the test conditions. Discussion & Conclusion: According to the results we concluded that multivariate stati-stical analyzes such as clustering, principal component analysis or correlation analysis helps to identify genes and groups of genes that transform normal tissue to a malignant stage. To identify the protein classes invol-ved in molecular mechanisms of cervical cancer need to determine the type of protein that must be identified by mass spectr-ometry.

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Introduction: With regard to the chara-cteristics of single-stranded oligonucle-otides, including their potential for implem-ental use in order to detect some key molec-ules, it was determined to gain experience in obtaining single-stranded DNA (ssDNA) having affinity for binding to morphine molecules. Materials, methods & Findings: An oligo-nucleotide library was prepared, consisting of an 80-nucleotide sequence with fixed length flanked by constant 5′ and 3′ ends, a 19-nucleotide sequence from 3′-end, a 21-nucleotide sequence from 5′-end that serve as primer, and a 40-nucleotide random seq-uence in the middle. Four types of nucleic acid and the 40-nucleotide sequence are mathematically equaled with 1015 DNA chains known as oligonucleotide pool. Af-ter amplification by PCR, the aptamers we-re exposed to the matrix-bound morphine molecules. After rinsing with a buffer and eliminating the chains, not bound to mor-phine molecule, they were separated using washing buffer, having potential to separate DNA chains from the target molecule. This act was repeated 15 times. Lastly, those primers were used in which one fluorescein molecule was placed at its 5′-end and flow cytometry results proved the efficiency of the chain in detection of target molecule (morphine). Discussion & Conclusion: Morphine mol-ecule was chosen due to its social and commercial importance for governments. For this reason, the separation of this nucl-eotide segment (oligonucleotide) was desi-gned by applying the experience of other researchers and some segments were event-ually obtained, which can be utilized inst-ead of monoclonal antibodies in detecting morphine in rapid kits after detection of sequences. Therefore, we enter to nanobi-ology and we will achieve applying olig-onucleotides in treatment, drug delivery into the target molecule, follow up the effect of the drug on cells, and finally help imaging.

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Introduction: Nowadays, cancer is the second cause of mortality in the world and among its variants the most common cancer in women is the breast cancer. One of the methods for cancer treatment is radioth-erapy, in which to enhance the efficiency of radiation therapy some of radio sensitizer can be used for enhancing tumor cell radiosensitivity. Some nanopa-rticles can be considered as a sensitizer because they enhance the cytotoxicity due to oxidative stress and increase the free radicals, especially reactive oxygen species (ROS), within cells resulting in cell death. In this study, elevated synergistic effect of TiO2 nanoparticles as radiosensitizer was evaluated in presence of cobalt-60 gamma rays on human breast cancer cell line. Materials & Methods: After cell culture, the human breast adenocarcinoma cell line (MCF-7 cells) was exposed to 2 Gy of radiation and 30 µg/ml concentration of the aforementioned nanoparticles. Viability was calculated using (3-[4, 5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) MTT assay. Findings: Viability of cells in presence of gamma radiation and the nanoparticles, sig-nificantly reduced compared to the viability of cells exposed only to radiation or nano-particle, alone. The effect may dependent on nanoparticle crystals type and conce-ntration. Discussion & Conclusion: Nano-TiO2 inc-reased sensitivity of breast cancer cells to gamma radiation, due to an increase in ROS production and cytotoxicity. Anatase crystals have more severe effects than rutile crystal because of having a larger surface area and creation of more free radicals. Therefore, this nanoparticle has the potent-ial to be used as a radiosensitizer.

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Introduction: Breast cancer is one of the most commonly diagnosed cancers among women worldwide. The aim of this study was to present the mortality trends from breast cancer among Iranian women from 1995 to 2004. Materials & Methods: We analyzed the National breast cancer death Statistic reported by the Iranian Ministry of Health and Medical Education from 1995 to 2004. Breast cancer was expressed as the annual mortality rates/100,000 and assorted by age and sex groups. Findings: The age standardized mortality rate of breast cancer increased dramatically, however it seems that the rate would be leveled off from 2002 to 2004. Discussion & Conclusion: There was an increasing trend for breast cancer mortality in Iran. Thus, a health education program would be necessary to enhance the knowledge of women about breast cancer signs and effectively screened the disease.

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Introduction: Results of some researches show that the strategies of people in response to stress stimuli play a crucial role in trapping the families in mental damages. The current study aimed to investigate the relationship between coping style and mental health along with considering the severity of drug addiction in addicted subjects in prevention centers of addiction in Gilan province. Materials & Methods: The research was a descriptive sectional study in which 251 addicted persons referring to prevention centers of addiction were selected rand-omly. For this reason, to collect required data the C.H.Q and G.H.Q questionnaires were utilized. The descriptive (mean, stand-ard, deviation and percent methods) and inferential statistics (correlation and reg-ression tests) were utilized to analyze the data. Findings: The results revealed that there is a significant relationship between coping style and emotional focused coping (r=61 %) and problems focused coping(r=44%), respectively. But, there was a negative correlation between avoidance coping and mental health (r=- 0.41) in addicted groups. Discussion & Conclusion: The relationship between detachment coping and mental health in addicted people showed that the-re was a negative relationship between the detachment coping and mental health situ-ation in lower level of addiction but there was a positive relationship in higher level of addiction.

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Abstract Introduction: the aim of this study was measurement of relation the social network and physical health aspect in the parents of mental retarded educatable students in Dezful city. Materials & Methods: In this correlation study, number of 226 parent of mental retarded educatable students from elementary and guidance schools in Dezful city, have selected randomly from society basis on the kokran formula. Norbeck Social Support Questionnaire for determination of social network and survey short form-36 health for determination of physical health have used in this way.for analyzing data Pearson correlation, Regression and variance analyze (ANOVA) have been used. Findings: Pearson correlation Coefficient and Liner Regression analyze suggested that there is a significant between social network and physical health aspect, genral health, physical functioning, role-physical and bodily pain in parents with educable mental retarded students (P<0.05). Discussion & Conclusion: this study shows that there is a positive and significant relation between social network and physical health aspect in the parents of mental retarded educatable student. Thus, social networks should be considered as important factors in developing health promotion programs for parent.

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Relationsheep btween Helicobacter pylory infection and Preeclampsia in women pregnant refer to shahyd mostafa khominy ilam town Najehe Bagheri M.S.C Sedigheh Amir AliAkbari M.S.C Mohammad Fasihy dastcherdy Koursh Sayehmiry Ph.D Nasrin Jamshidian B.S - Senior midwifery student Branch of the international Shahid Beheshti university of medical Sciences. 2- Faculty mentor and organ Shahid Behshti university of medical Sciences. 3- Assistant Professor of internal medicine in ilam university of medical Science 4 -. Assistant Professor of statistics in ilam university of medical Science 5 - Bacheler of midwifery student in ilam university of medical Science. Abstract: Objective: Preeclampsia one of major risk maternal morbidity and mortality.inflamation plays a pivotal role in the Preeclampsia The aim of this study was to compare Prevalence of plasma Helicobacter Pylori IgG between Preeclamptic and normal pregnant woman. Method: In a case control study, prevalence of 64 Patients with Preeclampsia and 64 normal pregnant women were chosen. Matching was done on age H. pylori serum Immunoglobulin IgG antibody Concentration were determined by enzyme- linked immunoadsorbent assay (ELISA). Data was analyzed using Chi-square, t-test, logistic Regresion and Roc Curve Results: Althought seropositive IgG against H. Pylori was higher in preeclamptic mothers. There was not any statistical significant association between prevalence of plasma Helicobacter Pylori (IgG) and preeclampsia OR= 1/79 (0/95 CI, 3/66- 0/88) Roc curve analysis show that IgG H.among weight and hypertention Drugs with Preeclampsia was meaning Association. pylori can predict 65preeclampsia the aria under ROC curve surface was %56 95% CI (0/46 – 0/66) Conclusion: IgG seropositive was no association of H. Pylori infection with Preeclampsia and mor than studies needs and larger namber to explainde these Association. . keywords: Preeclampsia, Helicobacter pylori , infection.

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Background & Aim: Colorectal cancer (CRC) is the third common type of cancer and the second leading cause of death in cancer. DNA damages and chromosomal instability are the greatest risk factors favoring the development of CRC. Exo1 is the only exonuclease involved in the MMR system. In this study because of the important role of Exo1 and in order to assess the susceptible biomarkers associated with the CRC , we have investigated the correlation between SNP of Exo1 gene rs1047840 and risk of CRC. Material & Method: This case-control study was performed on 118 cases and 130 healthy controls who had been referred to Taleghani hospital of Tehran. We analysed genotyping using polymerase chain reaction- restriction fragment length polymorphism and using MseI restriction enzyme. Results: According to our findings the frequencies of AA, AG,GG genotypes in control group were 49/3%, 43/8% and 6/9% and in patient group were 44/9%, 47/5% and 7/6% . The frequency of G and A allels were 71/2% and 28/8% in healthy controls and 68/6% and 31/4% in patients. Conclusions: Base on our findings, rs1047840 polymorphism is not associated with susceptibility to CRC and so we reached on a conclusion that this polymorphism possibly doesn’t have significant role in increasing or decreasing risk of CRC.

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Introduction: Cancer is the second cause of death in the world, and colon cancer is the third cause of cancer deaths. Assessment of factors which affect this cancer is important for prolonging the patient survival. The purpose of this study was to compare para-metric and Cox models as well as to deter-mine demographic and socioeconomic fact-ors affecting the 5-year survival of patients with colon cancer. Materials & Methods: In this survival stu-dy, population included 580 patients with colon cancer who were recorded in the Ca-ncer Research Center of Shahid Beheshti University of Medical Science from April 2005 to November 2006 and then were followed up for 5 years. Exponential, weib-ull, lognormal, log-logistic, and generalized gamma parametric models and Cox model were used to process the data. The models were compared with Akaike’s information criteria and Cox-Snell residual plot. Findings: Of 580 patients, 34% died. The age of patient during cancer diagnosis, gender, custody during childhood, residence location and afflicted organ were associated with the 5-year survival of patients. He calculated hazard ratios were nearly similar in different models. Based on Akaike’s inf-ormation criteria, the log-logistic and ext-ended gamma models were determined as better models, however based on Cox-Snell residual, the log-logistic and exponential models were determined as better models. Discussion & Conclusion: The result of study showed that the log-logistic model is a suitable model. Regarding the association between socioeconomic factor of residence location and 5-year survival of patients, the health promotion programs and planes is needed to improve the socioeconomic det-erminants of health status.

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Modern immunoinformatic approaches pro-vide new strategies for the identification, design and synthesis of antigen-specific ep-itops for different purposes such as vaccines production, allergies management, imm-unotherapy and etc. New developments in vaccine design, allergens identification and immunotherapy has been emerged follo-wing important discoveries in immune-ology and development of new epitope prediction tools/algorithms for B and T cells. Here, we initially attempted to intr-oduce immunoinformatic achievements to molecular biologist and then provide differ-rent approaches for B cell and T cell epito-pe prediction. Ideally, this article help rese-archer to find out more about epitope prediction methods and their challenges, how to use these approaches correctly and analysis their scientific data.

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Introduction: Since low adjustment is one of the main problems prisoners struggling with and considered to be one of the reasons for their tendency toward dangerous behaviors, this study was aimed at investigating the effect of desensitization by eye movements and reprocessing on enhancement of social, affective and health adjustment of prisoners. Method of study: This study was designed based on experimental method and by pretest and posttest model with control group. A sample of 40 individuals was taken (based on the type of their crimes) from prisoners in Ardebil's central jail with jail sentences as long as 4 months using stratified random sampling method. Rosenberg Self-Esteem Scale and Bel adjustment questionnaire were used to collect data which was completed in both pretest and posttest by experimental and control groups. Treatment of desensitization with eye movements and reprocessing was conducted during four sessions on experimental group and during which control group was not involved. . Data was analyzed using covariance analysis test. Findings: the results from this investigation indicated that the average grades for social, affective and health adjustment in experimental group were significantly higher than those in control group (P<0.001). Conclusion: treatment of desensitization by eye movements and reprocessing were effective on enhancing the adjustment of male prisoners. Therefore jails' psychologists can play a substantial role in enhancement of the adjustment of these people by teaching this short term treatment method and implementing it on sentenced people upon their entrance to jail.

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Abstract Background: The purpose of this study was to study the mediating role of neuroticism and Compromise in relationship between Sensation seeking and pre-addiction in students. Methods: The study population included 205 student (93 boys and 112 girls) of Ferdossi Mashad University that selected randomly through accessible sampling. Subjects completed sensation seeking, NEO-FFI and pre-addiction questionnaires. Data analyzed with interactional multiple regression. Result: This study showed that there was a positive significant relationship between sensation seeking and pre-addiction. But result of interactional multiple regression showed that just neuroticism had a mediating role in relationship between sensation seeking and pre-addiction. Conclusion: Whereas neuroticism had a mediating role we concluded that always sensation seeking and pre-addiction in regard to personal trait (neuroticism) have correlation.

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Introduction: Promotion and improvement of children's health is a part of the global obje-ctives of primary health care. This study inve-stigated psychometric characteristics of quality of life in elementary students of Kashan city in 2011. Materials & Methods: This cross-sectional study was performed on 400 elementary stud-ents (Grades 3 to 5) who were selected through random sampling. Content validity of the Per-sian version of the PedsQL 4.0 was checked and tested through the process of translating interview with children 9-12 years (N = 30) and their parents (N = 30) in the primary schools of the Kashan city. Construct validity and reliability of the PedsQL on the sample of elementary children in Kashan (N = 400) and their parents (N = 400) were tested. Criterion-related validity (concurrent) was estimated through investigating the correlation between child self-report of quality of life and parent proxy-report of quality of life along with demographic variables. Data were analyzed by using the SPSS V.18, and LISREL8.8 soft-wares. Findings: Totally, content validity of PedsQL was 0.84 and of the four subscales, physical, emotional, social, and school performances w-ere 0.80, 0.86, 0.83, and 0.88, respectively. Construct validity was good. (RMSEA = 0.047, NFI=0.99, GFI =1.00, P =0.15, df = 2, χ2 =3.77). All inquiries showed a moderate to higher than 0.40 loading over for four factors, physical, emotional, social, and school perfo-rmances. The correlation coefficient between the PedsQL and its four subscales were ace-ptable (r>0.7). The PedsQL had a good internal consistency (α =0.82). Cronbach alpha coefficients range of different categories of the mentioned tool was from 0.65 to 0.77. There was a significant relationship between PedsQL of children and parents and, also the demo-graphic characteristics of the population under study. Discusion & Conclusion: The findings indic-ated the suitability of psychometric properties of the Persian version of PedsQL to measure the quality of life in elementary students. Sch-ool administrators and health system profess-sionals can use this study to design guidelines for creating a healthy environment and devel-opment of the programs of health-based edu-cation in order to improve the quality of life and health of students

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Introduction: Among the cancers of women, breast and cervical cancers have the highest incidence and death rates. However, scre-ening programs are cheap, easy and acc-essible by which the cancers could be inhibited at early stages. This study aimed to investigate motivational factors and causes of nonparticipation to breast and cervical cancer screening among attending health centers in Kashan city. Material & Methods: This study was a cross-sectional one that was conducted on 233 women referring to health centers of Kashan. Sampling was made thro-ugh a two-stage cluster random sampling m-ethod. Data were collected through a questi-onnaire and then the data were analyzed by using SPSS V.14 software. Findings: Findings showed that 7.5 % of women under study were doing regular bre-ast self- examination. 21% of them had never done the Pap smear and only 22% of them were doing the Pap smear regularly. The most common motivatinal factors for screening were seriousness of cancer risk, access to the institutions of health for perf-orming examinations and recommendations. The most common reasons of nonpa-rticipation for screening were the lack of knowledge about the existence of such exa-minations, lack of knowledge on related centers to perform this examinations , no history of problem , fear and ashamed of the examinations. Discussion & Conclusion: Given the moti-vatinal factors and barriers for screening, the necessity of adequate training by health p-ersonnel was confirmed. Given the role of these individuals in promoting community health and their contribution, organizing of training programs in health centers would be very helpful to remove the barriers and strengthen motivators for screening of prevalent cancers among women

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Introduction: The pathological changes associated with multiple sclerosis (MS) produce changes in uniformity of the neural networks of brain white matter that result in more perceptible changes on diffusion tensor imaging (DTI). Increase in mean diffusivity (MD) and reduction in fractional anisotropy (FA) on DTI seen in MS patients may be due to the degradation of membrane or other cell structures. The aim of this study was to investigate the pathological changes made in the brains of MS patients using the DTI technique.
 Materials & methods: This study was performed on 15 patients with multiple sclerosis. To investigate the location of plaques and normal appearing white matter (NAWM) some routine protocols for the brain, including T2-FLAIR and T2, were taken and to normalize the images of DTI, the T1 MPRAGE protocol was applied. After image processing using SPM, FSL, and MedINRIA software, the data were analyzed with the Mann-Whitney test.
Findings: The results showed that there is a significant difference between the mean of MD (mean=4.3±1.01) and FA (mean=0.24±0.05) values in MS plaques and the mean of MD (mean=2.1±1.1) and FA (mean=0.55±0.56) values in the normal white matter (NWM) tissue of the control group (P=0.00001). Comparing the data obtained from the NAWM tissue with expanded disability status scale (EDSS) of patients showed that patients with higher EDSS show higher MD values (P=0.004) and lower FA values than patients with lower EDSS (P=0.001).
 Discussion & Conclusion: This study showed that factors of MD and FA in DTI technique can provide valuable information as imaging biomarkers about the MS plaques.

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Introduction: Beta thalassemia is a hereditary blood disorder characterized by anomalies in the synthesis of the beta chains of hemoglobin. Chorionic Villus Sampling (CVS) is used for fetal genotyping and as it is an invasive procedure, it has the risk of abortion. As a result, it is desirable to use a noninvasive method instead. The aim of this study was to present a noninvasive method for prenatal diagnosis of &beta-Thalassemia based on pattern of paternal polymorphism.

Materials & methods: In this study 30 families with the risk of thalassemia were screened. RFLP pattern of these families were identified and it was possible to investigate the transmission of paternal gene for thalassemia. Whole blood sample was drawn from mothers at gestation weeks 10-12 and their plasma was separated.

Findings: A cellular DNA of 7 plasma that contains DNA from both mother and fetus was investigated for RFLP informative sites of beta-globin gene.

Discussion & Conclusion: Although the amount of fetal DNA in plasma is less than maternal DNA, we could detect specific RFLP pattern of fetus and identified transmission of paternal allele.

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Introduction: Emotional disorders had immense impact on rehabilitation in the traumatic brain injury patients. This study is to investigate correlation of difficulties in emotional regulation in the mild traumatic brain injury patients compared with that in the normal people.

Materials & methods: This prospective cohort study was carried out on 72 mild traumatic brain injury (MTBI) victims and 72 other normal individuals in Shahid Beheshti hospital in Kashan city. Difficulties in Emotion Regulation (DERS), Positive and Negative Affect Schedule (PANAS) scales, demographic data, and related neurological questionnaires were used. The data were analyzed using T test, Chi square and multivariate linear regression.

Findings: The results of this study showed that mean standard deviations for emotional regulation were 112.6±21.8 and 93±14 in the TBI and control groups, respectively (P<0/001). In terms of PANAS, no significant difference was observed in both groups (P<0/001). Linear regression analysis in the TBI group demonstrated that (&beta;=20/4, P<0/001), age (&beta; – 0/339, P -0/01), familial history of mental disorder among first-grade relatives (&beta;- -9/419, P-0/01), economical status (&beta;-6/108, P-0/04), and history of underlying disease (&beta;-15/014, P-0.00) were predictor.

Discussion & Conclusions: Linear regression analysis of a few variables showed that being included in the patients group is the main effective variable on the difficulties in emotional regulation. Psychological cognitive rehabilitation therapy is one of the crucial meditation interventions in patients with traumatic brain.