Association of MMP-2(rs7201) and MMP-9(rs17576) genetic polymorphisms with the risk of endometriosis

Gushki, Raziyeh; Kohan, Leila

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Volume 32, Issue 3 (8-2024)

Journal of Ilam University of Medical Sciences 2024, 32(3): 65-75

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Association of MMP-2(rs7201) and MMP-9(rs17576) genetic polymorphisms with the risk of endometriosis

Raziyeh Gushki¹

, Leila Kohan ^*

1- Dept of Biology, Arsanjan branch, Islamic Azad University, Arsanjan, Iran
2- Dept of Biology, Arsanjan branch, Islamic Azad University, Arsanjan, Iran & Yong researchers and elite club, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran , leila_kohan@yahoo.com

Abstract: (255 Views)

Introduction: Endometriosis (EMS) is a female reproductive system disease in which uterine-like cells grow in other areas of the body and outside the uterus. Matrix metalloproteinases (MMPs) play a major role in the degradation of the extracellular matrix and the pathogenesis of endometriosis. The present study is the first to investigate the possible association of MMP-2 (rs7201) and MMP-9 (rs17576) genetic variants with susceptibility to EMS in Iran.
Material & Methods: This case-control study was performed on 100 healthy control women and 100 patients with EMS. The MMP-2 and MMP-9 genotypes were determined using the Tetra amplification-refractory mutation system-polymerase chain reaction (ARMS-PCR) Technique. Data were analyzed in SPSS software.
Results: There were statistically significant differences in the distribution of MMP-9 AG (OR: 4.11, 95% CI: 2.13-7.91, P<0.001) and GG (OR: 11.33, 95% CI: 4.23-30.3; P <0.001) genotypes between the control and patient groups. The MMP-9 G allele was associated with an increased risk of endometriosis (P<0.001). Moreover, a significant association was detected between MMP-2 rs7201 polymorphism and EMS. MMP-2 AC genotype had a protective effect on endometriosis (OR: 0.27. 95% CI: 0.15-49%; P<0.001), and the MMP-2 A allele was associated with decreased risk of endometriosis (P<0.001).
Discussion & Conclusion: As evidenced by the results of this study, MMP-9 rs17576 and MMP-2 rs7201 polymorphisms were associated with EMS in the studied population in Iran. Further studies with larger samples of different ethnicities need to confirm these results

Keywords: Endometriosis, MMP-9, MMP-2, rs7201, rs17576

Full-Text [PDF 1252 kb] (221 Downloads)

Type of Study: Research | Subject: biology
Received: 2023/07/3 | Accepted: 2024/04/22 | Published: 2024/08/5

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Gushki R, Kohan L. Association of MMP-2(rs7201) and MMP-9(rs17576) genetic polymorphisms with the risk of endometriosis. J. Ilam Uni. Med. Sci. 2024; 32 (3) :65-75
URL: http://sjimu.medilam.ac.ir/article-1-8026-en.html

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