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:: Volume 31, Issue 4 (10-2023) ::
Journal of Ilam University of Medical Sciences 2023, 31(4): 45-54 Back to browse issues page
Investigating the effectiveness of aerobic exercise along with nano curcumin supplementation in behavioral-motor disorders in rats with a brain tumor
Salmah Mohamadi1 , Hossein Shirvani * 2, Mehdi Roozbahani3 , Masoud Rahmati4
1- Dept of Exercise Physiology, Borujerd Branch, Islamic Azad University, Borujerd, Iran
2- Exercise Physiology Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran , shirvani.h2006@gmail.com
3- Dept of Motor Behavior, Borujerd Branch, Islamic Azad University, Borujerd, Iran
4- Dept of Sports Science, Faculty of Literature and Humanities, Lorestan University, Khorramabad, Iran
Abstract:   (992 Views)
Introduction: Any defect and abnormal growth in brain cells in an uncontrolled manner leads to the creation of a tumor and disruption of its normal functional capabilities. Therefore, the present study aimed to investigate the effectiveness of aerobic exercise along with nano curcumin supplementation in behavioral-motor disorders in rats with brain tumors.
Material & Methods: A total of 35 male Wistar rats were randomly assigned to seven groups of 5: basic healthy control, four weeks healthy, basic cancer control, four weeks cancer, cancer-nano curcumin, cancer-exercise, and cancer-exercise-nano curcumin groups. One week after the injection of cancer cells in the frontal cortex, the animals entered the main training program on the treadmill (4 weeks, with a speed of 18 meters per minute, 25-40 minutes, three days a week). The data were analyzed in SPSS software (version 26) using the statistical test of one-way analysis of variance.
Findings: The results pointed out that behavioral-motor disorders in the training group, nano curcumin, and the training group-nano curcumin were significantly less than in the 4-week cancer control group (P=0.001).
Discussion & Conclusion: It seems that aerobic exercise, along with a suitable dose of nano curcumin as a therapeutic supplement along with other methods, can reduce behavioral-motor disorders in cancerous rats, possibly by increasing brain blood flow, neurogenesis, and nerve synapses.
Keywords: Aerobic Exercise, Behavioral-motor disorders, Brain tumor, Nano curcumin supplement
Full-Text [PDF 816 kb]   (311 Downloads)    
Type of Study: Research | Subject: Physical Education
Received: 2023/02/18 | Accepted: 2023/07/5 | Published: 2023/10/7
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Mohamadi S, Shirvani H, Roozbahani M, Rahmati M. Investigating the effectiveness of aerobic exercise along with nano curcumin supplementation in behavioral-motor disorders in rats with a brain tumor. J. Ilam Uni. Med. Sci. 2023; 31 (4) :45-54
URL: http://sjimu.medilam.ac.ir/article-1-7886-en.html
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Volume 31, Issue 4 (10-2023) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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