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:: Volume 29, Issue 2 (5-2021) ::
Journal of Ilam University of Medical Sciences 2021, 29(2): 86-94 Back to browse issues page
Effect of Eight Weeks of Exercise with Different Intensities on the Gene Expression of Decorin and Muscular TGF-β in the Male Adult Rats
Elham Vosadi * 1, Farhad Gholami2 , Elham Mortazavi2
1- Dept of Sport Physiology, Faculty of Physical Education and Sports Sciences, Shahrood University of Technology, Shahrood, Iran , e.vosadi@yahoo.com
2- Dept of Sport Physiology, Faculty of Physical Education and Sports Sciences, Shahrood University of Technology, Shahrood, Iran
Abstract:   (1830 Views)
Introduction: This study aimed to investigate a period of exercise activity with different intensities on decorin gene expression through interaction with transforming growth factor-beta (TGF-β) in male adult rats.
 
Materials & Methods: This experimental study included 24 males adult Wistar rats that were divided into three groups (8 animals per group) of High-Intensity Training (HIT), Low-Intensity Training (LIT), and Control. Training groups trained for eight weeks and five days a week. The HIT group exercise program consisted of one hour of exercise for five 8-min intervals at 85%-90% Vo2max that were separated by 2-min intervals with an intensity of 50%-60% Vo2max. On the other hand, the LIT group exercise program included five 8-min intervals with an intensity of 55%-60% Vo2max, and 2-min intervals with an intensity of 45%-50% Vo2max. It should be noted that the control group received no exercise program.
 
Findings: The results of this study showed that the expression levels of the decorin gene in the HIT training group were significantly higher than those in the control group (P=0.001), whereas the levels of decorin in the LIT training groups were not significantly different from those in the control group (P=0.11). The expression levels of the TGF-β gene in both training intensities (high- and low-intensity training, respectively) showed a significant difference, compared to the control group (P=0.001, P=0.18).
 
Discussions & Conclusions: According to the results of the present study, it seems that HIT exercise can lead to a greater increase in muscle growth due to increased TGF-β-dependent myokine, compared to LIT exercise.
Keywords: Decorin, TGF-β, High intensity training, Low intensity training, Male adult rat
Full-Text [PDF 1233 kb]   (736 Downloads)    
Type of Study: Research | Subject: Physical Education
Received: 2020/10/12 | Accepted: 2021/03/2 | Published: 2021/05/31
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Vosadi E, Gholami F, Mortazavi E. Effect of Eight Weeks of Exercise with Different Intensities on the Gene Expression of Decorin and Muscular TGF-β in the Male Adult Rats. J. Ilam Uni. Med. Sci. 2021; 29 (2) :86-94
URL: http://sjimu.medilam.ac.ir/article-1-6800-en.html
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Volume 29, Issue 2 (5-2021) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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