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The effect of the opium addiction on histological structure of liver and kidney in rabbits
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| A Loui monfared, S Mami *1, A p Salati |
| 1- , s.mami@ilam.ac.ir , |
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Abstract: (143507 Views) |
| Introduction: Morphine is a potent analgesic and narcotic drug that is found in opium. It is also an endocrine substance in humans and animals. This medication is used to treat mild to severe pain. This study was done to evaluate the histopathological effects of opium on liver and kidney.
Material and methods: 60 rabbits (30 male and 30 female) weighing 300-250 g were divided into control and addicts, randomly. Addicted rabbits received 25 mg / case / day opium by gavage. This rate gradually over a period of one week to 100 mg / case / day and kept on to day 60. At the end of period rabbits were euthanized, kidney and liver tissues were removed and fixed in formalin. Routine histological methods was done to prepare slides and stained with H&E.
Results: our findings showed that in rabbits treated with opium the dilation of collecting tubules, dilation on interestisium, sever hemorrhage, hypertrophy and hyperplasia of renal corpuscles was recorded. In liver hyperemia in central veins, presence of inflammatory cells, fatty change, necrosis of hepatocytes and enlarging the sinusoids was seen.
Conclusion: Morphine caused Structural abnormalities in liver and kidney. With respect to our findings, histological changes and dysfunction in kidney and liver could be considered as problems in addicted. |
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| Keywords: opium, rabbit, histology, liver |
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Full-Text [PDF 528 kb]
(14485 Downloads)
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Type of Study: Research |
Subject:
animal physiology
Received: 2012/06/26 | Accepted: 2013/09/24 | Published: 2013/09/24
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