Introduction: According to previous research, Cucurbita pepo L. increases sex hormones in males. The purpose of this study was to survey the effect of Cucurbita pepo on the histomorphometrical changes of testes induced by ethanol administration in male Wistar rats.
 
Materials & Methods: Twenty male Wistar rats were divided into four groups of five as follows: 1- Control group, 2- Experimental group1 (received 20% ethanol  [1 mg/gr, i.p.] for 30 days), 3- Experimental group2 (received 20% ethanol [1 mg/gr, i.p.] along with Cucurbita pepo as 20% of their meal for 30 days), and 4- Experimental group3 (received 20% ethanol (1 mg/gr, i.p.) along with Cucurbita pepo as 80% of their meal for 30 days).
 
Findings: Results showed that seminiferous tubule wall thickness, weight of the testes, and the number of spermatogenic cells were decreased in the Experimental group1. However, all these parameters were increased in the Experimental group3 compared to the Experimental group1. These reductions in the Experimental group1 in comparison with the control group were significantly different. However, all these parameters had increased in the Experimental group3 compared to the control group with no significant difference, while they were significantly different from experimental groups 1 and 2.
 
Discusion & Conclusions: It is concluded that high doses of Cucurbita pepo (80%) may prevent reduced number of spermatogenic cells caused by the consumption of alcohol. However, low doses of Cucurbita pepo (20%) cannot impede the destructive effects of alcohol.