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Stability of Gd-porphyrins as a contrast agent of magnetic resonance imaging in mice
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Abstract: (14520 Views) |
| Abstract
Introduction: Gd-hematoporphyrin(Gd-H) was used along with human colorectal cancer cells (HT29/219) as a contrast agent in nuclear magnetic resonance (NMR) to measure the stability of Gd-H in mice.
Materials & Methods: Human colorectal cancer cells (HT29/219) were injected in flank of 20 (four groups of five) mice. Three to four weeks after tumor implantations, when the tumor diameter was 3-5 mm, the mice were injected with Gd-H contrast agent. The animals were slaughtered at 7, 24 and 72 hours post injection, followed by removal of critical organs (liver, kidney) and the tumor. These organs were minced for MR imaging and UV-spect.
Findings: The biggest of T1 relaxation times of liver and kidney were found after 24 h and 72h, respectively. The most signal intensity in liver and kidney was revealed after 24h and 72h, respectively. The most concentration of Gd in tumor occurs 24h after the injection.
Conclusion: The data of T1 relaxation time, signal intensity and concentration of Gd showed that the stability of Gd-H is more than 72 hours after the injection in mice. |
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| Keywords: : Gd-porphyrin, colon cancer cell, magnetic resonance imaging, contrast agent |
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Full-Text [PDF 493 kb]
(2958 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2009/01/27 | Accepted: 2015/04/21 | Published: 2015/04/21
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