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The Role of Rapid Delayed Rectifier K+Current on Pacemaker
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Abstract: (14286 Views) |
| Abstract
Introduction: In the heart cells, rapid delayed rectifier K+current is one of the important currents for action potential repolarization phase. Rapid delayed rectifier K+current is blocked by low concentration of E-4031. The aim of this research was to compare the effect of E-4031 blocker on pacemaker activity of sinoatrial node (SAN) and atrioventricular node (AVN) of mouse heart.
Materials & methodes: The pacemaker activity of distinct intact SAN and AVN by two separate metal microelectrodes that contact the endothelial surface of nodes, was recorded before and during 1M E-4031 and cycle length (CL) was measured.
Findings: 1 M E-4031 increased CL on SAN preparations by 67.6 ±12.5 % and on AVN preparations by 28±3.5 %. These changes were significants in two nodes.
Conclusion: It is passible to conclude that 1) the rapid delayed rectifier K+current was present in two nodes 2) the effect of E-4031 on CL of two nodes was differen |
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| Keywords: sinoatrial node (SAN), atrioventricular node(AVN), cycle length(CL), rapid delayed rectifier K+current, E-4031 |
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Full-Text [PDF 349 kb]
(3324 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2009/01/27 | Accepted: 2015/04/20 | Published: 2015/04/20
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