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:: Volume 16, Issue 2 (7-2008) ::
Journal of Ilam University of Medical Sciences 2008, 16(2): 21-27 Back to browse issues page
The Role of Rapid Delayed Rectifier K+Current on Pacemaker
Abstract:   (13891 Views)
Abstract Introduction: In the heart cells, rapid delayed rectifier K+current is one of the important currents for action potential repolarization phase. Rapid delayed rectifier K+current is blocked by low concentration of E-4031. The aim of this research was to compare the effect of E-4031 blocker on pacemaker activity of sinoatrial node (SAN) and atrioventricular node (AVN) of mouse heart. Materials & methodes: The pacemaker activity of distinct intact SAN and AVN by two separate metal microelectrodes that contact the endothelial surface of nodes, was recorded before and during 1M E-4031 and cycle length (CL) was measured. Findings: 1 M E-4031 increased CL on SAN preparations by 67.6 ±12.5 % and on AVN preparations by 28±3.5 %. These changes were significants in two nodes. Conclusion: It is passible to conclude that 1) the rapid delayed rectifier K+current was present in two nodes 2) the effect of E-4031 on CL of two nodes was differen
Keywords: sinoatrial node (SAN), atrioventricular node(AVN), cycle length(CL), rapid delayed rectifier K+current, E-4031
Full-Text [PDF 349 kb]   (2920 Downloads)    
Type of Study: Research | Subject: General
Received: 2009/01/27 | Accepted: 2015/04/20 | Published: 2015/04/20
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The Role of Rapid Delayed Rectifier K+Current on Pacemaker . J. Ilam Uni. Med. Sci. 2008; 16 (2) :21-27
URL: http://sjimu.medilam.ac.ir/article-1-33-en.html

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Volume 16, Issue 2 (7-2008) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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