Introduction: Diabetes is a metabolic disorder, which is characterized by hyperglycemia resulting from defects in insulin secretion and impaired pancreatic function. With regard to the medicinal properties of amaranth, this study was conducted to investigate the effects of amaranth on skin histomorphological changes in diabetic rats.

Materials & methods:  In this study, 48 male Wistar rats were divided into four groups (control group, sham group, first experimental group, and second experimental group). After general anesthesia with ketamine and xylazine in groups of mice. In these rats, an injured area of 4cm2 was created on the left spine. The control groups had no ointment and first experimental group was treated with eucerin ointment. In addition, second experimental group was treated using pomegranate fat and eucerin ointment twice daily. Wound healing was evaluated macroscopically. Microscopic study were assigned to another article.

Findings: Wound healing in group that became diabetes using streptozocin, showed late recovery compared to normal wound healing in normal groups and wound healing in experimental groups treated with Pumice Granum was accelerated compared to control group.

Discussion & conclusions: Results of this study showed Pumice Granum causes accelerated skin wound healing in normal and diabetic samples.