Introduction: Among the growing concerns over recent decades in the field of environmental pollution, is the use of antibiotics increase bacterial resistance to antibiotics used in human body. The aim of this study was to determine the effectiveness of the Ciprofloxacin antibiotic removal from the aquatic environment. 

Material & methods: This empirical study was performed at useful volume of one liter, using 4-electrode reactor made of iron with area of 40 cm2 , in the ultrasonic device with fixed frequency 40 KHz. The effect of variables such as pH, antibiotic concentrations, the amount of hydrogen peroxide, current density were studied. was studied concentration of ciprofloxacin antibiotic was determined using HPLC wavelength of 275 nm, and due to the experimental and in laboratory condition, studies have been conducted, finally the average of the results were used. The concentration of COD was measured to ensure optimal efficacy of the process.

Findings: The results showed that all variables can be effective on ciprofloxacin removal. The removal efficiency in the optimal conditions of pH=3, H2O2 concentration 150 mg/L, current density of 15 mA/cm2, the initial concentration of antibiotics 10 mg/L and a reaction time of 15 minutes was 97% and COD removal of 40 percent. Evaluated ion concentration was about 157 g/m3. In  these conditions, the removal efficiency of electrofenton and ultrasonic was 75 and 3 percent respectively.

Discussion & Conclusion: Based on the results of this study, the electrofenton is a suitable process for the removal of the antibiotic ciprofloxacin. The simultaneous use of this process  with ultrasonic , namely sono-electrofenton, has enhanced its efficiency.