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:: Volume 31, Issue 5 (12-2023) ::
Journal of Ilam University of Medical Sciences 2023, 31(5): 70-84 Back to browse issues page
Effect of eight weeks of aerobic and resistance training on adropin, spexin, and TNFα levels, as well as insulin resistance indices, in obese men with type 2 diabetes
Mahdiyeh Shamizadeh * 1, Mohamad Reza Zolfaghari2 , Amir Fattahi3
1- Dept of Exercise Physiology, Faculty of Sports Sciences, Urmia University, Urmia, Iran , mahdiyeh.shamizadeh91@gmail.com
2- Dept of Exercise Physiology, Faculty of Sports Sciences, Urmia University, Urmia, Iran
3- Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract:   (934 Views)
Introduction: Energy homeostasis as a metabolic control pathway can be investigated from different dimensions. The present study aimed to assess the effect of eight weeks of aerobic and resistance training on adropin, spexin, and TNFa, as well as insulin resistance indices, in obese men with type 2 diabetes.
Material & Methods: In this quasi-experimental study, 30 obese men with type 2 diabetes in khoy in 2022 were selected and randomly assigned to three groups: control, aerobic exercise, and resistance exercise. Aerobic and resistance training (three sessions per week) was performed for eight weeks. In the pre-test and post-test stages, the levels of serum adropin, spexin, and TNFa, as well as the indices of insulin resistance and insulin sensitivity, were measured. Data were analyzed in SPSS software (version 24) using Shapiro-Wilk, t-test correlated, and one-way analysis of variance test to investigate intra-group and inter-group effects, respectively.
Results: Aerobic and resistance training causes significant changes in fat percentage, fasting blood sugar, cholesterol, triglyceride, HDL, and LDL in obese men with type 2 diabetes (P≤0/05). Moreover, in the between-group comparison, aerobic exercise causes significant changes in mean blood pressure, insulin, Insulin resistance index (HOMA-IR), adropin, and spexin levels in obese men with type 2 diabetes (P≤0/05).
Conclusion: Participation in an aerobic exercise program with moderate intensity exerts more marked effects on adropin and spexin indices compared to resistance exercise. It is recommended to consider aerobic training programs in diabetic people as an effective factor in therapeutic intervention.
Keywords: Adropin, Aerobic Training, Insulin Resistance, Spexin, Type 2 Diabetes
Full-Text [PDF 1126 kb]   (297 Downloads)    
Type of Study: Research | Subject: Physical Education
Received: 2023/06/5 | Accepted: 2023/10/21 | Published: 2023/12/6
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Shamizadeh M, Zolfaghari M R, Fattahi A. Effect of eight weeks of aerobic and resistance training on adropin, spexin, and TNFα levels, as well as insulin resistance indices, in obese men with type 2 diabetes. J. Ilam Uni. Med. Sci. 2023; 31 (5) :70-84
URL: http://sjimu.medilam.ac.ir/article-1-7995-en.html


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Volume 31, Issue 5 (12-2023) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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