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:: Volume 26, Issue 6 (3-2019) ::
Journal of Ilam University of Medical Sciences 2019, 26(6): 143-155 Back to browse issues page
The Effect of Compulsory Sports Activities on Substantia Nigra Tissue and Behavioral Tests Induction Parkinsons Model with 6-Hydroxydopamine in Prenatal Stress Rats
Toraj Mohammad zamani1 , Ahmadreza Movahedi * 2, Elahe Arab ameri3
1- Dept of Physical Education and Sport Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
2- Dept of Motor Behavior, Faculty of Physical Education, University of Isfahan, Isfahan, Iran , armovahedi@yahoo.com
3- Dept of Motor Behavior, Faculty of Physical Education, university of Tehran, Tehran, Iran
Abstract:   (3634 Views)
Introduction: Prenatal stress causes brain alteration and prolongs effects on structure and function. Parkinson's is a progressive neurodegenerative disease And one of the factors motive Parkinson's is the Prenatal stress. Exercising activity is a good way to prevent the disease. The aim of this study was to investigate the effect of mandatory exercise on Substantia nigra tissue in Perinatal Parkinson's rats.
 
Materials & Methods: A Laboratory research method was used. 48 Wistar male rats, half of them under prenatal stress And followed up on compulsory sports activities. Were divided into 8 groups of 6, with stress (control, sham, Parkinson, Parkinson + compulsory exercise) and without stress (control, sham, Parkinson, Parkinson + compulsory exercise). the animals received Stereotaxic Surgery after 8 weeks, Three weeks later, Parkinson's symptoms were evaluated using Apo morphine rotation test and Wire grasping. The number of substantia nigra neurons in the brain is counted using a microscope; Data were analyzed using One-Way ANOVA and Tukey's Post Test.
Ethics code: IR.IAU.SRB.REC.1396
 
Findings: In groups with and without stress, the number of substantia nigra neurons compulsory sports group was different from that of the control group and this difference was statistically significant (P=0.0000). The average number of substantia nigra neurons compulsory sports group in both groups with and without stress difference was low, but statistically significant (P=0.014).
 
Discussion & conclusions: The results refer to the effects of compulsive exercise on the better protection of Substantia nigra neurons and suggests that exercise can be effective as a beneficial factor in reducing the degeneration of dopaminergic neurons in Parkinson's disease. Prenatal stress also reduces the beneficial effects of exercise.
 
Keywords: Compulsory sports, Prenatal stress, Substantia nigra tissue, Parkinson’s disease
Full-Text [PDF 1060 kb]   (1286 Downloads)    
Type of Study: Research |
Received: 2018/06/2 | Accepted: 2018/10/15 | Published: 2019/03/15
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Mohammad zamani T, Movahedi A, Arab ameri E. The Effect of Compulsory Sports Activities on Substantia Nigra Tissue and Behavioral Tests Induction Parkinsons Model with 6-Hydroxydopamine in Prenatal Stress Rats . J. Ilam Uni. Med. Sci. 2019; 26 (6) :143-155
URL: http://sjimu.medilam.ac.ir/article-1-5013-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 26, Issue 6 (3-2019) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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