1. Raegrant A, Day GS, Marrie RA, Rabinstein A, Cree BA, Gronseth GS, et al. Practice guideline recommendations summary disease modifying therapies for adults with multiple sclerosis report of the guideline development and dissemination and implementation subcommittee of the american academy of neurology. Neurology 2018;90:777-88. doi. 10.1212/WNL.0000000000005347.

2. Sherwood DE. The benefits of random variable practice for spatial accuracy and error detection in a rapid aiming task. Res Quart Exe Sport 1996;67:35-43. doi.10.1080/02701367.1996.10607923

3. George C, Ebers MD. Neurobehavioral aspects of multiple sclerosis. Arch Neurol 1991;48:897. doi.10.1001/archneur.1991.00530210023005

4. Voss MW, Vivar C, Kramer AF. Bridging animal and human models of exercise induced brain plasticity. Trends Cogn Sci 2013;17:525-44. doi. 10.1016/j.tics.2013.08.001.

5. Azoulay D, Vachapova V, Shihman B, Miler A, Karni A. Lower brain derived neurotrophic factor in serum of relapsing remitting MS reversal by glatiramer acetate. J Neuroimmunol 2005;167:215-8. doi.10.1016/j.jneuroim.2005.07.001

6. Frota ERC, Rodrigues DH, Donadi EA, Brum DG, Maciel DRK, Teixeira AL. Increased plasma levels of brain derived neurotrophic factor after multiple sclerosis relapse. Neurosci let 2009;460:130-2. doi.10.1016/j.neulet.2009.05.057.

7. Griffin EW, Mullally S, Foley C, Warmington SA, Omara SM, Kelly AM. Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiol Behavior 2011;104:934-41. doi.10.1016/j.physbeh.2011.06.005.

8. Zimmermann-Schlatter A, Schuster C, Puhan MA, Siekierka E, Steurer J. Efficacy of motor imagery in post-stroke rehabilitation: a systematic review. J Neuroengine Rehabil 2008;5:8. doi. 10.1186/1743-0003-5-8.

9. Christensen W, Sutton J, Mcilwain DJJM, Language. Cognition in skilled action meshed control and the varieties of skill experience. Mind Lang 2016;31:37-66. doi.10.1111/mila.12094.

10. Wakefield C, Smith D, Moran AP, Holmes P. Functional equivalence or behavioural matching? A critical reflection on 15 years of research using the PETTLEP model of motor imagery. Int Rev Sport Exe Psychol 2013;6:105-21. doi.10.1080/1750984X.2012.724437.

11. Heremans E, D’hooge A-M, De Bondt S, Helsen W, Feys P. The relation between cognitive and motor dysfunction and motor imagery ability in patients with multiple sclerosis. Mul Sclero J 2012;18:1303-9. doi.10.1177/1352458512437812.

12. Holmes P, Collins D. The PETTLEP approach to motor imagery a functional equivalence model for sport psychologists. J Appl Sport Psychol2017; 13:13:60-83. doi.10.1080/10413200109339004.

13. Zich C, Debener S, Schweinitz C, Sterr A, Meekes J, Kranczioch C. High intensity chronic stroke motor imagery neurofeedback training at home three case reports. Clin EEG Neurosci2017;48:403-12. doi.10.1177/1550059417717398

14. Caligiore D, Mustile M, Spalletta G, Baldassarre G. Action observation and motor imagery for rehabilitation in Parkinson's disease a systematic review and an integrative hypothesis. Neurosci Biobehavior Rev 2017;72:210-22. doi.10.1016/j.neubiorev.2016.11.005

15. Hallett M, Iseki K. Real and imaginary gait. Movement Disorders 2012;27(12):1473-4. doi: 10.1002/mds.25186.

16. Ozkul C, Guclugunduz A, Irkec C, Fidan I, Aydin Y, Ozkan T, et al. Effect of combined exercise training on serum brain derived neurotrophic factor suppressors of cytokine signaling 1 and 3 in patients with multiple sclerosis. J Neuroimmunol 2018;316:121-9. doi.10.1016/j.jneuroim.2018.01.002.

17. Wens I, Keytsman C, Deckx N, Cools N, Dalgas U. Brain derived neurotrophic factor in multiple sclerosis effect of 24 weeks endurance and resistance training. European J Neurol 2016;23:1028-35. doi.10.1111/ene.12976

18. Euston DR, Gruber AJ, McNaughton BLJN. The role of medial prefrontal cortex in memory and decision Making. 2012;76:1057-70. doi:10.1016/j.neuron.2012.12.002

19. Vaughan S, Wallis M, Polit D, Steele M, Shum D, Morris N. The effects of multimodal exercise on cognitive and physical functioning and brain derived neurotrophic factor in older women a randomised controlled trial. Age Age2014;43:623-9. doi.10.1093/ageing/afu010

20. Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, et al. Exercise training increases size of hippocampus and improves memory. Proce National Acad Sci 2011;108:3017-22. doi.10.1073/pnas.1015950108.

21. Preston AR, Eichenbaum HJCB. Interplay of hippocampus and prefrontal cortex in memory. Cur Biol 2013;23: 764-73. doi.10.1016/j.cub.2013.05.041.

22. Angelucci F, Peppe A, Carlesimo GA, Serafini F, Zabberoni S, Barban F, et al. A pilot study on the effect of cognitive training on BDNF serum levels in individuals with Parkinson disease. Frontiers Hum Neurosci 2015;9:130. doi.10.3389/fnhum.2015.00130.

23. He YY, Zhang XY, Yung WH, Zhu JN, Wang JJ. Role of BDNF in central motor structures and motor diseases. Mole Neurobiol 2013;48:783-93.doi.10.1007/s12035-013-8466-y

24. Woo NH, Lu B. Regulation of cortical interneurons by neurotrophins from development to cognitive disorders. Neuroscientist 2006;12:43-56. doi.10.1177/1073858405284360

25. Sakata K, Martinowich K, Woo NH, Schloesser RJ, Jimenez DV, Ji Y, et al. Role of activity-dependent BDNF expression in hippocampal–prefrontal cortical regulation of behavioral perseverance. Proceedings of the National Academy of Sciences. 2013:201222872. doi: 10.1073/pnas.1222872110

26. Maass A, Duzel S, Brigadski T, Goerke M, Becke A, Sobieray U, et al. Relationships of peripheral IGF-1 and VEGF and BDNF levels to exercise related changes in memory hippocampal perfusion and volumes in older adults. Neuroimage 2016;131:142-54. doi. 10.1016/j.neuroimage.2015.10.084.

27. Volk LJ, Bachman JL, Johnson R, Yu Y, Huganir RLJN. PKM is not required for hippocampal synaptic plasticity learning and memory. Nature 2013;493:420. doi.10.1038/nature11802.

28. Turrigiano GJ. Homeostatic synaptic plasticity local and global mechanisms for stabilizing neuronal function. Cold Spring Harb Per Biol 2012;4:5736. doi: 10.1101/cshperspect.a005736.

29. Madhav T, Pei Q, Zetterström T. Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine kinase B the high affinity receptor for brain derived neurotrophic factor. Mole Brain Res 2001;93:56-63. doi.10.1016/S0169-328X(01)00183-8

30. Krupp LB. Fatigue in multiple sclerosis a guide to diagnosis and management. 1 th ed. Demos Med Publication. 2004;P.114-9.